ID   6.3.2.25
DE   tubulin--tyrosine ligase.
AN   TTL.
CA   C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine
CA   + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-
CA   [tubulin] + ADP + phosphate + H(+).
CC   -!- L-Tyrosine is linked via a peptide bond to the C-terminus of
CC       de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin).
CC   -!- The enzyme is highly specific for alpha-tubulin and moderately
CC       specific for ATP and L-tyrosine.
CC   -!- L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but
CC       with higher Km values.
DR   P38584, TTL_BOVIN  ;  Q8NG68, TTL_HUMAN  ;  P38585, TTL_MOUSE  ;
DR   P38160, TTL_PIG    ;  Q9QXJ0, TTL_RAT    ;  Q10438, TTL_SCHPO  ;
DR   P38254, TTL_YEAST  ;
//