ID 6.3.2.26 DE N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase. AN ACV synthetase. AN L-alpha-aminoadipyl-cysteinyl-valine synthetase. AN L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase. CA 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + CA 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl- CA D-valine. CC -!- The enzyme contains 4'-phosphopantetheine, which may be involved in CC the mechanism of the reaction. CC -!- Forms part of the penicillin biosynthesis pathway. DR P27742, ACVA_EMENI ; P25464, ACVA_HAPCH ; P19787, ACVA_PENCH ; DR B6HLU1, ACVA_PENRW ; P27743, ACVS_AMYLA ; Q01757, ACVS_STRCL ; //