ID   6.3.2.47
DE   dapdiamide synthase.
AN   dapdiamide A synthase.
CA   (1) 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine +
CA   L-valine + ATP = dapdiamide E + ADP + phosphate + H(+).
CA   (2) N(3)-fumaramoyl-(S)-2,3-diaminopropanoate + L-valine + ATP =
CA   dapdiamide A + ADP + phosphate + H(+).
CA   (3) N(3)-fumaramoyl-(S)-2,3-diaminopropanoate + L-isoleucine + ATP =
CA   dapdiamide B + ADP + phosphate + H(+).
CA   (4) N(3)-fumaramoyl-(S)-2,3-diaminopropanoate + L-leucine + ATP =
CA   dapdiamide C + ADP + phosphate + H(+).
CC   -!- The enzyme, characterized from the bacterium Pantoea agglomerans,
CC       is involved in biosynthesis of dapdiamide tripeptide antibiotics,
CC       a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the
CC       presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide
CC       linkages in their scaffold.
DR   E2JA31, DDAF_ENTAG ;
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