ID   6.3.4.21
DE   nicotinate phosphoribosyltransferase.
AN   niacin ribonucleotidase.
AN   nicotinic acid mononucleotide glycohydrolase.
AN   nicotinic acid mononucleotide pyrophosphorylase.
AN   nicotinic acid phosphoribosyltransferase.
CA   5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP +
CA   diphosphate + nicotinate beta-D-ribonucleotide + phosphate.
CC   -!- The enzyme, which is involved in pyridine nucleotide recycling,
CC       can form beta-nicotinate D-ribonucleotide and diphosphate from
CC       nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the
CC       absence of ATP.
CC   -!- However, when ATP is available the enzyme is phosphorylated resulting
CC       in a much lower Km for nicotinate.
CC   -!- The phospho-enzyme is hydrolyzed during the transferase reaction,
CC       regenerating the low affinity form.
CC   -!- The presence of ATP shifts the products/substrates equilibrium from
CC       0.67 to 1100.
CC   -!- Formerly EC 2.4.2.11.
DR   Q8RWM2, NPRT1_ARATH;  Q84WV8, NPRT2_ARATH;  Q9UTK3, NPT1_SCHPO ;
DR   P39683, NPT1_YEAST ;  P9WJI8, PNCB1_MYCTO;  P9WJI9, PNCB1_MYCTU;
DR   Q9HUP4, PNCB1_PSEAE;  P9WJI6, PNCB2_MYCTO;  P9WJI7, PNCB2_MYCTU;
DR   Q9HW26, PNCB2_PSEAE;  Q6F6W1, PNCB_ACIAD ;  B2I1P1, PNCB_ACIBC ;
DR   A3MA25, PNCB_ACIBT ;  B9MHC7, PNCB_ACIET ;  A1W8S8, PNCB_ACISJ ;
DR   Q8UIS9, PNCB_AGRFC ;  B9JYR4, PNCB_ALLAM ;  O32090, PNCB_BACSU ;
DR   A1UUA2, PNCB_BARBK ;  Q6G5H6, PNCB_BARHE ;  Q6G0X7, PNCB_BARQU ;
DR   A9ILN1, PNCB_BART1 ;  Q7WCZ8, PNCB_BORBR ;  Q7W5G3, PNCB_BORPA ;
DR   A9IIC5, PNCB_BORPD ;  Q7VTF7, PNCB_BORPE ;  A5PK51, PNCB_BOVIN ;
DR   Q89SS3, PNCB_BRADU ;  A5E8V7, PNCB_BRASB ;  A4YK54, PNCB_BRASO ;
DR   B2S8A9, PNCB_BRUA1 ;  Q2YNV6, PNCB_BRUA2 ;  A6WV52, PNCB_BRUA4 ;
DR   Q57FQ9, PNCB_BRUAB ;  A9M757, PNCB_BRUC2 ;  C0RGH3, PNCB_BRUMB ;
DR   Q8YEP2, PNCB_BRUME ;  B0CIM5, PNCB_BRUSI ;  Q8G340, PNCB_BRUSU ;
DR   B8D9E6, PNCB_BUCA5 ;  P57442, PNCB_BUCAI ;  Q8K9I6, PNCB_BUCAP ;
DR   B8D7P8, PNCB_BUCAT ;  B1YVJ0, PNCB_BURA4 ;  A0K5S6, PNCB_BURCH ;
DR   Q0BH38, PNCB_BURCM ;  Q62LW1, PNCB_BURMA ;  B1JY80, PNCB_BURO0 ;
DR   Q1BXX4, PNCB_BURO1 ;  Q63S63, PNCB_BURPS ;  A4JCM8, PNCB_BURVG ;
DR   Q95XX1, PNCB_CAEEL ;  Q11HJ2, PNCB_CHESB ;  Q1QZ10, PNCB_CHRSD ;
DR   Q7NSK2, PNCB_CHRVO ;  A8AIE5, PNCB_CITK8 ;  A7MEW8, PNCB_CROS8 ;
DR   Q0K8J9, PNCB_CUPNH ;  Q6P3H4, PNCB_DANRE ;  C0QFM5, PNCB_DESAH ;
DR   Q55G10, PNCB_DICDI ;  Q9VQX4, PNCB_DROME ;  A7ZK22, PNCB_ECO24 ;
DR   B7UN17, PNCB_ECO27 ;  B7MHP0, PNCB_ECO45 ;  B7LE31, PNCB_ECO55 ;
DR   Q8XDE8, PNCB_ECO57 ;  B5YT65, PNCB_ECO5E ;  B7NM43, PNCB_ECO7I ;
DR   B7MS49, PNCB_ECO81 ;  B7M860, PNCB_ECO8A ;  C4ZQ57, PNCB_ECOBW ;
DR   B1X8N5, PNCB_ECODH ;  A7ZYN4, PNCB_ECOHS ;  Q8FJ98, PNCB_ECOL6 ;
DR   P18133, PNCB_ECOLI ;  B7N398, PNCB_ECOLU ;  B6I904, PNCB_ECOSE ;
DR   B1LJT2, PNCB_ECOSM ;  C5BD56, PNCB_EDWI9 ;  A4W8V0, PNCB_ENT38 ;
DR   B2VC92, PNCB_ERWT9 ;  B7LNU8, PNCB_ESCF3 ;  A4G168, PNCB_HERAR ;
DR   Q6XQN6, PNCB_HUMAN ;  Q8TMW6, PNCB_METAC ;  Q12Z05, PNCB_METBU ;
DR   Q8PSJ3, PNCB_METMA ;  Q8CC86, PNCB_MOUSE ;  Q5F836, PNCB_NEIG1 ;
DR   B4RL23, PNCB_NEIG2 ;  A9M0T9, PNCB_NEIM0 ;  Q9JTM8, PNCB_NEIMA ;
DR   Q9JYM9, PNCB_NEIMB ;  Q1QI14, PNCB_NITHX ;  Q6D454, PNCB_PECAS ;
DR   C6DFB8, PNCB_PECCP ;  Q7N621, PNCB_PHOLL ;  Q6LRA6, PNCB_PHOPR ;
DR   Q128P8, PNCB_POLSJ ;  B4EVC0, PNCB_PROMH ;  Q48NY1, PNCB_PSE14 ;
DR   A4XS60, PNCB_PSEMY ;  A5W9Q6, PNCB_PSEP1 ;  Q3KIW4, PNCB_PSEPF ;
DR   B0KKX3, PNCB_PSEPG ;  Q88DF7, PNCB_PSEPK ;  Q87VL5, PNCB_PSESM ;
DR   Q4ZYV7, PNCB_PSEU2 ;  A1SVJ9, PNCB_PSYIN ;  Q8Y0L2, PNCB_RALN1 ;
DR   B2U8V2, PNCB_RALPJ ;  Q6XQN1, PNCB_RAT   ;  B3PXL5, PNCB_RHIE6 ;
DR   Q2KDT0, PNCB_RHIEC ;  Q98D24, PNCB_RHILO ;  B5ZWU4, PNCB_RHILW ;
DR   Q92S49, PNCB_RHIME ;  B9J6S5, PNCB_RHIR8 ;  B5F1U0, PNCB_SALA4 ;
DR   A9MHU8, PNCB_SALAR ;  Q57QZ3, PNCB_SALCH ;  B5FQ81, PNCB_SALDC ;
DR   B5QZD8, PNCB_SALEP ;  B5R8M1, PNCB_SALG2 ;  B4TDS5, PNCB_SALHS ;
DR   B4T172, PNCB_SALNS ;  Q5PGD8, PNCB_SALPA ;  A9N6Y6, PNCB_SALPB ;
DR   C0PXX2, PNCB_SALPC ;  B5BBM4, PNCB_SALPK ;  B4TRW6, PNCB_SALSV ;
DR   Q8Z7Y9, PNCB_SALTI ;  P22253, PNCB_SALTY ;  A8GCJ6, PNCB_SERP5 ;
DR   B2TUE4, PNCB_SHIB3 ;  Q31YR6, PNCB_SHIBS ;  Q32E52, PNCB_SHIDS ;
DR   Q83LN3, PNCB_SHIFL ;  Q3Z3I9, PNCB_SHISS ;  C3MFW1, PNCB_SINFN ;
DR   A6U5X9, PNCB_SINMW ;  Q2NU84, PNCB_SODGM ;  Q9HJ28, PNCB_THEAC ;
DR   A1WJL0, PNCB_VEREI ;  A7N4I5, PNCB_VIBC1 ;  A5F1F1, PNCB_VIBC3 ;
DR   Q9KN67, PNCB_VIBCH ;  C3LUC2, PNCB_VIBCM ;  Q87JE4, PNCB_VIBPA ;
DR   Q8DA38, PNCB_VIBVU ;  Q7MK41, PNCB_VIBVY ;  Q8PGU5, PNCB_XANAC ;
DR   Q3BPD5, PNCB_XANC5 ;  Q4UQS8, PNCB_XANC8 ;  B0RVE9, PNCB_XANCB ;
DR   Q8PCP3, PNCB_XANCP ;  Q9PED1, PNCB_XYLFA ;  Q87EC4, PNCB_XYLFT ;
DR   A1JMP2, PNCB_YERE8 ;  A7FJU4, PNCB_YERP3 ;  Q8ZG93, PNCB_YERPE ;
DR   Q66CG6, PNCB_YERPS ;
//