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ENZYME

ENZYME entry: EC 6.4.1.10

PURL: https://purl.expasy.org/enzyme/EC/6.4.1.10
Accepted Name
atromentin synthase
Reaction catalysed
2 3-(4-hydroxyphenyl)pyruvate + 2 ATP = atromentin + 2 AMP + 2 diphosphate + H(+)
Comment(s)
  • Requires Mg(2+).
  • The enzyme, found in some such as members of the Boletales and Eurotiales order, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain.
  • The enzyme activates 3-(4-hydroxyphenyl)pyruvate by adenylation and catalyzes the dimerization/cyclization of two such molecules to form atromentin.
  • Atromentin is a precursor for assorted metabolites produced by the fungi, including pulvinic acids and 2,5-diarylcyclopentenones.
Cross-references
Rhea expert-curated reactions6.4.1.10
ExplorEnz6.4.1.10
IUBMB Enzyme Nomenclature6.4.1.10
BRENDA6.4.1.10
MetaCyc6.4.1.10
KEGG Ligand Database for Enzyme Nomenclature6.4.1.10
MEDLINEFind literature relating to 6.4.1.10

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-