Expasy logo

ENZYME

ENZYME entry: EC 6.4.1.12

PURL: https://purl.expasy.org/enzyme/EC/6.4.1.12
Accepted Name
didemethylasterriquinone D synthase
Reaction catalysed
2 indole-3-pyruvate + 2 ATP = didemethylasterriquinone D + 2 AMP + 2 diphosphate + H(+)
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the fungus Aspergillus nidulans, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain.
  • The enzyme activates (indol-3-yl)pyruvate by adenylation and catalyzes the dimerization/cyclization of two such molecules to form didemethylasterriquinone D.
  • Didemethylasterriquinone D is subsequently converted to terrequinone A, a cytotoxic compound that displays a broad range of bioactivities.
Cross-references
Rhea expert-curated reactions6.4.1.12
ExplorEnz6.4.1.12
IUBMB Enzyme Nomenclature6.4.1.12
BRENDA6.4.1.12
MetaCyc6.4.1.12
KEGG Ligand Database for Enzyme Nomenclature6.4.1.12
MEDLINEFind literature relating to 6.4.1.12

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-