ID   6.4.1.12
DE   didemethylasterriquinone D synthase.
CA   2 indole-3-pyruvate + 2 ATP = didemethylasterriquinone D + 2 AMP +
CA   2 diphosphate + H(+).
CC   -!- Requires Mg(2+).
CC   -!- The enzyme, characterized from the fungus Aspergillus nidulans, is a
CC       non-ribosomal peptide synthase-like enzyme comprising three domains -
CC       an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a
CC       thioesterase (TE) domain.
CC   -!- The enzyme activates (indol-3-yl)pyruvate by adenylation and
CC       catalyzes the dimerization/cyclization of two such molecules to form
CC       didemethylasterriquinone D.
CC   -!- Didemethylasterriquinone D is subsequently converted to terrequinone
CC       A, a cytotoxic compound that displays a broad range of bioactivities.
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