ID   6.5.1.1
DE   DNA ligase (ATP).
AN   DNA joinase.
AN   DNA repair enzyme.
AN   polydeoxyribonucleotide synthase (ATP).
AN   polynucleotide ligase (ATP).
AN   sealase.
CA   ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CA   (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
CC   -!- The enzyme catalyzes the ligation of DNA strands with 3'-hydroxyl and
CC       5'-phosphate termini, forming a phosphodiester and sealing certain
CC       types of single-strand breaks in duplex DNA.
CC   -!- Catalysis occurs by a three-step mechanism, starting with the
CC       activation of the enzyme by ATP, forming a phosphoramide bond between
CC       adenylate and a lysine residue.
CC   -!- The adenylate group is then transferred to the 5'-phosphate terminus
CC       of the substrate, forming the capped structure
CC       5'-(5'-diphosphoadenosine)-[DNA].
CC   -!- Finally, the enzyme catalyzes a nucleophilic attack of the 3'-OH
CC       terminus on the capped terminus, which results in formation of the
CC       phosphodiester bond and release of the adenylate.
CC   -!- RNA can also act as substrate, to some extent. cf. EC 6.5.1.2,
CC       EC 6.5.1.6 and EC 6.5.1.7.
DR   Q42572, DNLI1_ARATH;  Q27474, DNLI1_CAEEL;  Q869E1, DNLI1_DICDI;
DR   Q9W1H4, DNLI1_DROME;  Q18HT7, DNLI1_HALWD;  P18858, DNLI1_HUMAN;
DR   B1L3K8, DNLI1_KORCO;  Q8TSR7, DNLI1_METAC;  Q46C04, DNLI1_METBF;
DR   Q8PVR7, DNLI1_METMA;  P37913, DNLI1_MOUSE;  Q9JHY8, DNLI1_RAT  ;
DR   P12000, DNLI1_SCHPO;  A1RXA6, DNLI1_THEPD;  P51892, DNLI1_XENLA;
DR   P04819, DNLI1_YEAST;  Q18GX5, DNLI2_HALWD;  B1L3V2, DNLI2_KORCO;
DR   Q8TMT1, DNLI2_METAC;  Q46BA3, DNLI2_METBF;  Q8PTK1, DNLI2_METMA;
DR   A1RY72, DNLI2_THEPD;  Q54QM4, DNLI3_DICDI;  P49916, DNLI3_HUMAN;
DR   P97386, DNLI3_MOUSE;  Q9C1W9, DNLI3_SCHPO;  Q9LL84, DNLI4_ARATH;
DR   Q4WVG8, DNLI4_ASPFU;  Q2U6A1, DNLI4_ASPOR;  P52496, DNLI4_CANAL;
DR   Q6FVD8, DNLI4_CANGA;  Q90YB1, DNLI4_CHICK;  Q1DKE7, DNLI4_COCIM;
DR   A8N936, DNLI4_COPC7;  Q7Z7W5, DNLI4_COPCI;  G3GTP0, DNLI4_CRIGR;
DR   P0CN09, DNLI4_CRYNB;  P0CN08, DNLI4_CRYNJ;  Q54CR9, DNLI4_DICDI;
DR   Q5BH83, DNLI4_EMENI;  Q75CA4, DNLI4_EREGS;  P49917, DNLI4_HUMAN;
DR   Q6CSH0, DNLI4_KLULA;  Q8BTF7, DNLI4_MOUSE;  Q7SB49, DNLI4_NEUCR;
DR   Q7X7E9, DNLI4_ORYSJ;  Q0UCI9, DNLI4_PHANO;  Q5R6L3, DNLI4_PONAB;
DR   O74833, DNLI4_SCHPO;  Q6C8A3, DNLI4_YARLI;  Q08387, DNLI4_YEAST;
DR   Q02093, DNLI_ACIAM ;  B8JBM1, DNLI_ANAD2 ;  Q2IH69, DNLI_ANADE ;
DR   A7HID3, DNLI_ANADF ;  B4UIS1, DNLI_ANASK ;  O67398, DNLI_AQUAE ;
DR   O29632, DNLI_ARCFU ;  P35970, DNLI_ASFB7 ;  P0C992, DNLI_ASFK5 ;
DR   P26813, DNLI_ASFM2 ;  P0C990, DNLI_ASFP4 ;  P0C991, DNLI_ASFWA ;
DR   C5BW79, DNLI_BEUC1 ;  P07717, DNLI_BPT3  ;  P00970, DNLI_BPT4  ;
DR   P19088, DNLI_BPT6  ;  P00969, DNLI_BPT7  ;  A8MDU6, DNLI_CALMQ ;
DR   A0RWD6, DNLI_CENSY ;  B5YD88, DNLI_DICT6 ;  B8DZX8, DNLI_DICTD ;
DR   Q67480, DNLI_FOWPN ;  P44121, DNLI_HAEIN ;  B9LUZ9, DNLI_HALLT ;
DR   Q5V4R0, DNLI_HALMA ;  B0R4C9, DNLI_HALS3 ;  Q9HR35, DNLI_HALSA ;
DR   D4GYZ4, DNLI_HALVD ;  A8AB20, DNLI_IGNH4 ;  A6WG40, DNLI_KINRD ;
DR   Q1II25, DNLI_KORVE ;  A6UVC4, DNLI_META3 ;  Q0W0X1, DNLI_METAR ;
DR   A7IAA9, DNLI_METB6 ;  Q12X08, DNLI_METBU ;  Q2FTH4, DNLI_METHJ ;
DR   Q57635, DNLI_METJA ;  Q8TWN3, DNLI_METKA ;  A2SR38, DNLI_METLZ ;
DR   A4FY19, DNLI_METM5 ;  A9AAX4, DNLI_METM6 ;  A6VFQ9, DNLI_METM7 ;
DR   A3CWP1, DNLI_METMJ ;  Q6LYM1, DNLI_METMP ;  B8GGB8, DNLI_METPE ;
DR   A5UKX2, DNLI_METS3 ;  A4YD25, DNLI_METS5 ;  Q2NHF9, DNLI_METST ;
DR   P54875, DNLI_METTF ;  Q50566, DNLI_METTH ;  A0B7F9, DNLI_METTP ;
DR   A6UNY0, DNLI_METVS ;  A0A7H0DNE6, DNLI_MONPV ;  A0QJL0, DNLI_MYCA1 ;
DR   Q7TTR7, DNLI_MYCBO ;  A1KN60, DNLI_MYCBP ;  C1AGI1, DNLI_MYCBT ;
DR   A4TDS2, DNLI_MYCGI ;  B2HHE1, DNLI_MYCMM ;  Q73V97, DNLI_MYCPA ;
DR   A0QUP1, DNLI_MYCS2 ;  A3PXE2, DNLI_MYCSJ ;  A1UDY9, DNLI_MYCSK ;
DR   Q1BB26, DNLI_MYCSS ;  A5U776, DNLI_MYCTA ;  P9WNV4, DNLI_MYCTO ;
DR   P9WNV5, DNLI_MYCTU ;  A0PTC0, DNLI_MYCUA ;  A1T6P2, DNLI_MYCVP ;
DR   Q74M64, DNLI_NANEQ ;  Q3IPX0, DNLI_NATPD ;  A9A3K1, DNLI_NITMS ;
DR   Q5YNY7, DNLI_NOCFA ;  A1SKL2, DNLI_NOCSJ ;  Q9YMV2, DNLI_NPVLD ;
DR   B1ZZL9, DNLI_OPITP ;  C0QSL7, DNLI_PERMH ;  Q6L195, DNLI_PICTO ;
DR   B8HCE1, DNLI_PSECP ;  P0CL75, DNLI_PYRAB ;  O93723, DNLI_PYRAE ;
DR   A4WH24, DNLI_PYRAR ;  P0CL74, DNLI_PYRAY ;  A3MS62, DNLI_PYRCJ ;
DR   P56709, DNLI_PYRFU ;  O59288, DNLI_PYRHO ;  A1RTK4, DNLI_PYRIL ;
DR   B1YA52, DNLI_PYRNV ;  Q0SG75, DNLI_RHOJR ;  C1AX87, DNLI_RHOOB ;
DR   A4F870, DNLI_SACEN ;  Q980T8, DNLI_SACS2 ;  Q9P9K9, DNLI_SACSH ;
DR   A9GU24, DNLI_SORC5 ;  Q826P6, DNLI_STRAW ;  Q9FCB1, DNLI_STRCO ;
DR   B1W5J2, DNLI_STRGG ;  Q4JAM1, DNLI_SULAC ;  C3MZR1, DNLI_SULIA ;
DR   C4KIZ2, DNLI_SULIK ;  C3MJ14, DNLI_SULIL ;  C3MYD2, DNLI_SULIM ;
DR   C3NF77, DNLI_SULIN ;  C3N834, DNLI_SULIY ;  Q976G4, DNLI_SULTO ;
DR   Q9HJ26, DNLI_THEAC ;  Q979A1, DNLI_THEVO ;  O57250, DNLI_VACCA ;
DR   P20492, DNLI_VACCC ;  P16272, DNLI_VACCW ;  P0DOO3, DNLI_VAR67 ;
DR   P0DOO4, DNLI_VARV  ;  F4HPZ9, LIG6_ARATH ;  A0R5T2, LIGC1_MYCS2;
DR   A0R5T3, LIGC2_MYCS2;  L0TDE1, LIGC_MYCTU ;  O34398, LIGD_BACSU ;
DR   P59971, LIGD_MYCBO ;  A0R3R7, LIGD_MYCS2 ;  P9WNV2, LIGD_MYCTO ;
DR   P9WNV3, LIGD_MYCTU ;  Q9I1X7, LIGD_PSEAE ;  O54003, REP75_PYRAB;
DR   P03631, REPA_BPPHS ;  P19189, REP_BPCHP  ;  P69546, REP_BPF1   ;
DR   P69545, REP_BPFD   ;  P15419, REP_BPI22  ;  O80302, REP_BPIF1  ;
DR   P03660, REP_BPIKE  ;  P69547, REP_BPM13  ;  P03627, REP_BPPF3  ;
DR   Q38617, REP_BPPHL  ;  Q9G050, REP_BPPHM  ;  P11334, REP_SPV4   ;
//