ID   7.1.1.1
DE   proton-translocating NAD(P)(+) transhydrogenase.
CA   H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+).
CC   -!- The enzyme is a membrane bound proton-translocating pyridine
CC       nucleotide transhydrogenase that couples the reversible reduction of
CC       NADP by NADH to an inward proton translocation across the membrane.
CC   -!- In the bacterium Escherichia coli the enzyme provides a major source
CC       of cytosolic NADPH.
CC   -!- Detoxification of reactive oxygen species in mitochondria by
CC       glutathione peroxidases depends on NADPH produced by this enzyme.
CC   -!- Formerly EC 1.6.1.2 and EC 1.6.1.5.
DR   P11024, NNTM_BOVIN ;  Q13423, NNTM_HUMAN ;  Q61941, NNTM_MOUSE ;
DR   W5PFI3, NNTM_SHEEP ;  Q2RSB2, PNTAA_RHORT;  P0C186, PNTAA_RHORU;
DR   P41077, PNTAA_RICPR;  Q2RSB3, PNTAB_RHORT;  P0C187, PNTAB_RHORU;
DR   P51995, PNTAB_RICPR;  Q9ALA2, PNTA_CERSP ;  P07001, PNTA_ECOLI ;
DR   P43842, PNTA_HAEIN ;  P0AB69, PNTB_ECO57 ;  P0AB68, PNTB_ECOL6 ;
DR   P0AB67, PNTB_ECOLI ;  P43010, PNTB_HAEIN ;  Q2RSB4, PNTB_RHORT ;
DR   P0C188, PNTB_RHORU ;  P0AB70, PNTB_SHIFL ;
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