Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.4.2.1

Accepted Name
ABC-type polar-amino-acid transporter.
Alternative Name(s)
Histidine permease.
Polar-amino-acid-transporting ATPase.
Reaction catalysed
ATP + H(2)O + polar amino acid-[polar amino acid-binding protein](Side 1) <=> ADP + phosphate + polar amino acid(Side 2) + [polar amino acid-binding protein](Side 1)
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids.
  • This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.
  • Formerly EC 3.6.3.21.
Cross-references
PROSITEPDOC00185
BRENDA7.4.2.1
EC2PDB7.4.2.1
ExplorEnz7.4.2.1
PRIAM enzyme-specific profiles7.4.2.1
KEGG Ligand Database for Enzyme Nomenclature7.4.2.1
IUBMB Enzyme Nomenclature7.4.2.1
IntEnz7.4.2.1
MEDLINEFind literature relating to 7.4.2.1
MetaCyc7.4.2.1
UniProtKB/Swiss-Prot
P0AAG4, GLTL_ECO57;  P0AAG3, GLTL_ECOLI;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-