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ENZYME

ENZYME entry: EC 7.4.2.1

PURL: https://purl.expasy.org/enzyme/EC/7.4.2.1
Accepted Name
ABC-type polar-amino-acid transporter
Alternative Name(s)
histidine permease
polar-amino-acid-transporting ATPase
Reaction catalysed
a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + phosphate + H(+)
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids.
  • This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.
  • Formerly EC 3.6.3.21.
Cross-references
BRENDA7.4.2.1
EC2PDB7.4.2.1
ExplorEnz7.4.2.1
KEGG Ligand Database for Enzyme Nomenclature7.4.2.1
IUBMB Enzyme Nomenclature7.4.2.1
MEDLINEFind literature relating to 7.4.2.1
MetaCyc7.4.2.1
Rhea expert-curated reactions7.4.2.1
UniProtKB/Swiss-Prot
Q8NQU4, ARGV_CORGLP0AAF8, ARTP_ECO57P0AAF7, ARTP_ECOL6
P0AAF6, ARTP_ECOLIP45092, ARTP_HAEINP0AAF9, ARTP_SHIFL
P0AAG4, GLTL_ECO57P0AAG3, GLTL_ECOLIQ8RQL7, GLUA_COREF
P48243, GLUA_CORGLP07109, HISP_ECOLIQ9HZS1, HISP_PSEAE
P02915, HISP_SALTY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-