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ENZYME entry: EC 7.4.2.12

Accepted Name
ABC-type cystine transporter.
Alternative Name(s)
Cystine ABC transporter.
Cystine transporting ATPase.
Reaction catalysed
  • ATP + H(2)O + L-cystine-[cystine-binding protein](Side 1) <=> ADP + phosphate + L-cystine(Side 2) + [cystine-binding protein](Side 1)
  • ATP + H(2)O + D-cystine-[cystine-binding protein](Side 1) <=> ADP + phosphate + D-cystine(Side 2) + [cystine-binding protein](Side 1)
Comment(s)
  • ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine.
  • The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
Cross-references
BRENDA7.4.2.12
EC2PDB7.4.2.12
ExplorEnz7.4.2.12
PRIAM enzyme-specific profiles7.4.2.12
KEGG Ligand Database for Enzyme Nomenclature7.4.2.12
IUBMB Enzyme Nomenclature7.4.2.12
IntEnz7.4.2.12
MEDLINEFind literature relating to 7.4.2.12
MetaCyc7.4.2.12
UniProtKB/Swiss-Prot
P37774, TCYN_ECOLI

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