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ENZYME

ENZYME entry: EC 7.4.2.12

Accepted Name
ABC-type cystine transporter
Alternative Name(s)
cystine ABC transporter
cystine transporting ATPase
Reaction catalysed
  • ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate
  • ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate
Comment(s)
  • ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine.
  • The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.
Cross-references
BRENDA7.4.2.12
EC2PDB7.4.2.12
ExplorEnz7.4.2.12
PRIAM enzyme-specific profiles7.4.2.12
KEGG Ligand Database for Enzyme Nomenclature7.4.2.12
IUBMB Enzyme Nomenclature7.4.2.12
IntEnz7.4.2.12
MEDLINEFind literature relating to 7.4.2.12
MetaCyc7.4.2.12
Rhea expert-curated reactions7.4.2.12
UniProtKB/Swiss-Prot
P37774, TCYN_ECOLI

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