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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.4.2.3

Accepted Name
Mitochondrial protein-transporting ATPase.
Reaction catalysed
ATP + H(2)O + mitochondrial-protein(Side 1) <=> ADP + phosphate + mitochondrial-protein(Side 2)
Comment(s)
  • A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex.
  • TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
  • Formerly EC 3.6.3.51.
Cross-references
BRENDA7.4.2.3
EC2PDB7.4.2.3
ExplorEnz7.4.2.3
PRIAM enzyme-specific profiles7.4.2.3
KEGG Ligand Database for Enzyme Nomenclature7.4.2.3
IUBMB Enzyme Nomenclature7.4.2.3
IntEnz7.4.2.3
MEDLINEFind literature relating to 7.4.2.3
MetaCyc7.4.2.3

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-