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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Mitochondrial protein-transporting ATPase.
Reaction catalysed
ATP + H(2)O + mitochondrial-protein(Side 1) <=> ADP + phosphate + mitochondrial-protein(Side 2)
  • A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex.
  • TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
  • Formerly EC
PRIAM enzyme-specific profiles7.4.2.3
KEGG Ligand Database for Enzyme Nomenclature7.4.2.3
IUBMB Enzyme Nomenclature7.4.2.3
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-