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ENZYME

ENZYME entry: EC 7.6.2.1

PURL: https://purl.expasy.org/enzyme/EC/7.6.2.1
Accepted Name
P-type phospholipid transporter
Alternative Name(s)
flippase
phospholipid-transporting ATPase
Reaction catalysed
ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2
Comment(s)
  • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • Different forms of the enzyme move phospholipids such as phosphatidylcholine, lyso-phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidyglycerol, sphingomyelin and glucosylceramide from one membrane face to the other ('flippase').
  • Formerly EC 3.6.3.1.
Cross-references
BRENDA7.6.2.1
EC2PDB7.6.2.1
ExplorEnz7.6.2.1
KEGG Ligand Database for Enzyme Nomenclature7.6.2.1
IUBMB Enzyme Nomenclature7.6.2.1
MEDLINEFind literature relating to 7.6.2.1
MetaCyc7.6.2.1
Rhea expert-curated reactions7.6.2.1
UniProtKB/Swiss-Prot
O95477, ABCA1_HUMANP41233, ABCA1_MOUSEQ99758, ABCA3_HUMAN
Q8R420, ABCA3_MOUSEA0A0G2K1Q8, ABCA3_RATF1MWM0, ABCA4_BOVIN
P78363, ABCA4_HUMANO35600, ABCA4_MOUSEQ8IZY2, ABCA7_HUMAN
Q86UK0, ABCAC_HUMANE9Q876, ABCAC_MOUSEQ9LI83, ALA10_ARATH
Q9SAF5, ALA11_ARATHP57792, ALA12_ARATHP98204, ALA1_ARATH
P98205, ALA2_ARATHQ9XIE6, ALA3_ARATHQ9LNQ4, ALA4_ARATH
Q9SGG3, ALA5_ARATHQ9SLK6, ALA6_ARATHQ9LVK9, ALA7_ARATH
Q9LK90, ALA8_ARATHQ9SX33, ALA9_ARATHO60312, AT10A_HUMAN
O54827, AT10A_MOUSEO94823, AT10B_HUMANB1AWN4, AT10B_MOUSE
Q9P241, AT10D_HUMANQ9GKS6, AT10D_MACFAQ8K2X1, AT10D_MOUSE
P98196, AT11A_HUMANP98197, AT11A_MOUSEQ9Y2G3, AT11B_HUMAN
Q6DFW5, AT11B_MOUSEQ9N0Z4, AT11B_RABITQ8NB49, AT11C_HUMAN
Q9QZW0, AT11C_MOUSEQ29449, AT8A1_BOVINQ9Y2Q0, AT8A1_HUMAN
P70704, AT8A1_MOUSEC7EXK4, AT8A2_BOVINQ9NTI2, AT8A2_HUMAN
P98200, AT8A2_MOUSEO43520, AT8B1_HUMANQ148W0, AT8B1_MOUSE
D4AA47, AT8B1_RATQ5BL50, AT8B1_XENTRP98198, AT8B2_HUMAN
P98199, AT8B2_MOUSEO60423, AT8B3_HUMANQ6UQ17, AT8B3_MOUSE
Q8TF62, AT8B4_HUMANA3FIN4, AT8B5_MOUSEO94296, ATC3_SCHPO
G2X7W6, ATC3_VERDVP39524, ATC3_YEASTQ12675, ATC4_YEAST
G0S196, ATC5_CHATDP32660, ATC5_YEASTQ10309, ATC7_SCHPO
P40527, ATC7_YEASTQ9UT43, ATC8_SCHPOQ12674, ATC8_YEAST
Q09891, ATCX_SCHPOO36028, ATCZ_SCHPOO75110, ATP9A_HUMAN
O70228, ATP9A_MOUSEA1A4J6, ATP9B_BOVINF1Q4S1, ATP9B_DANRE
O43861, ATP9B_HUMANP98195, ATP9B_MOUSED4ABB8, ATP9B_RAT
P21447, MDR1A_MOUSEP06795, MDR1B_MOUSEP21448, MDR1_CRIGR
P08183, MDR1_HUMANP43245, MDR1_RATP23174, MDR3_CRIGR
P21439, MDR3_HUMANP21440, MDR3_MOUSEQ08201, MDR3_RAT
Q9U280, TAT1_CAEELG5EBH1, TAT5_CAEEL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.2.-
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