ENZYME entry: EC 7.6.2.1

Accepted Name

P-type phospholipid transporter

Alternative Name(s)

flippase

phospholipid-transporting ATPase

Reaction catalysed

ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2

Comment(s)

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
Different forms of the enzyme move phospholipids such as phosphatidylcholine, lyso-phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidyglycerol, sphingomyelin and glucosylceramide from one membrane face to the other ('flippase').
Formerly EC 3.6.3.1.

Cross-references

BRENDA

7.6.2.1

EC2PDB

7.6.2.1

ExplorEnz

7.6.2.1

PRIAM enzyme-specific profiles

7.6.2.1

KEGG Ligand Database for Enzyme Nomenclature

7.6.2.1

IUBMB Enzyme Nomenclature

7.6.2.1

IntEnz

7.6.2.1

MEDLINE

Find literature relating to 7.6.2.1

MetaCyc

7.6.2.1

Rhea expert-curated reactions

7.6.2.1

UniProtKB/Swiss-Prot

O95477, ABCA1_HUMAN	P41233, ABCA1_MOUSE	Q99758, ABCA3_HUMAN
Q8R420, ABCA3_MOUSE	A0A0G2K1Q8, ABCA3_RAT	F1MWM0, ABCA4_BOVIN
P78363, ABCA4_HUMAN	O35600, ABCA4_MOUSE	Q8IZY2, ABCA7_HUMAN
Q86UK0, ABCAC_HUMAN	E9Q876, ABCAC_MOUSE	Q9LI83, ALA10_ARATH
Q9SAF5, ALA11_ARATH	P57792, ALA12_ARATH	P98204, ALA1_ARATH
P98205, ALA2_ARATH	Q9XIE6, ALA3_ARATH	Q9LNQ4, ALA4_ARATH
Q9SGG3, ALA5_ARATH	Q9SLK6, ALA6_ARATH	Q9LVK9, ALA7_ARATH
Q9LK90, ALA8_ARATH	Q9SX33, ALA9_ARATH	O60312, AT10A_HUMAN
O54827, AT10A_MOUSE	O94823, AT10B_HUMAN	B1AWN4, AT10B_MOUSE
Q9P241, AT10D_HUMAN	Q9GKS6, AT10D_MACFA	Q8K2X1, AT10D_MOUSE
P98196, AT11A_HUMAN	P98197, AT11A_MOUSE	Q9Y2G3, AT11B_HUMAN
Q6DFW5, AT11B_MOUSE	Q9N0Z4, AT11B_RABIT	Q8NB49, AT11C_HUMAN
Q9QZW0, AT11C_MOUSE	Q29449, AT8A1_BOVIN	Q9Y2Q0, AT8A1_HUMAN
P70704, AT8A1_MOUSE	C7EXK4, AT8A2_BOVIN	Q9NTI2, AT8A2_HUMAN
P98200, AT8A2_MOUSE	O43520, AT8B1_HUMAN	Q148W0, AT8B1_MOUSE
D4AA47, AT8B1_RAT	Q5BL50, AT8B1_XENTR	P98198, AT8B2_HUMAN
P98199, AT8B2_MOUSE	O60423, AT8B3_HUMAN	Q6UQ17, AT8B3_MOUSE
Q8TF62, AT8B4_HUMAN	A3FIN4, AT8B5_MOUSE	O94296, ATC3_SCHPO
G2X7W6, ATC3_VERDV	P39524, ATC3_YEAST	Q12675, ATC4_YEAST
G0S196, ATC5_CHATD	P32660, ATC5_YEAST	Q10309, ATC7_SCHPO
P40527, ATC7_YEAST	Q9UT43, ATC8_SCHPO	Q12674, ATC8_YEAST
Q09891, ATCX_SCHPO	O36028, ATCZ_SCHPO	O75110, ATP9A_HUMAN
O70228, ATP9A_MOUSE	A1A4J6, ATP9B_BOVIN	F1Q4S1, ATP9B_DANRE
O43861, ATP9B_HUMAN	P98195, ATP9B_MOUSE	D4ABB8, ATP9B_RAT
P21447, MDR1A_MOUSE	P06795, MDR1B_MOUSE	P21448, MDR1_CRIGR
P08183, MDR1_HUMAN	P43245, MDR1_RAT	P23174, MDR3_CRIGR
P21439, MDR3_HUMAN	P21440, MDR3_MOUSE	Q08201, MDR3_RAT
Q9U280, TAT1_CAEEL	G5EBH1, TAT5_CAEEL

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