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ENZYME entry: EC 7.6.2.1

Accepted Name
P-type phospholipid transporter.
Alternative Name(s)
Flippase.
Phospholipid-transporting ATPase.
Reaction catalysed
ATP + H(2)O + phospholipid(Side 1) <=> ADP + phosphate + phospholipid(Side 2)
Comment(s)
  • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • Different forms of the enzyme move phospholipids such as phosphatidylcholine, lyso-phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidyglycerol, sphingomyelin and glucosylceramide from one membrane face to the other ('flippase').
  • Formerly EC 3.6.3.1.and EC 3.6.3.13.
Cross-references
PROSITEPDOC00139
BRENDA7.6.2.1
EC2PDB7.6.2.1
ExplorEnz7.6.2.1
PRIAM enzyme-specific profiles7.6.2.1
KEGG Ligand Database for Enzyme Nomenclature7.6.2.1
IUBMB Enzyme Nomenclature7.6.2.1
IntEnz7.6.2.1
MEDLINEFind literature relating to 7.6.2.1
MetaCyc7.6.2.1
Rhea expert-curated reactions7.6.2.1
UniProtKB/Swiss-Prot
O95477, ABCA1_HUMAN;  P41233, ABCA1_MOUSE;  Q99758, ABCA3_HUMAN;  
Q8R420, ABCA3_MOUSE;  A0A0G2K1Q8, ABCA3_RAT;  P78363, ABCA4_HUMAN;  
O35600, ABCA4_MOUSE;  Q8IZY2, ABCA7_HUMAN;  Q86UK0, ABCAC_HUMAN;  
E9Q876, ABCAC_MOUSE;  Q9LI83, ALA10_ARATH;  Q9SAF5, ALA11_ARATH;  
P57792, ALA12_ARATH;  P98204, ALA1_ARATH;  P98205, ALA2_ARATH;  
Q9XIE6, ALA3_ARATH;  Q9LNQ4, ALA4_ARATH;  Q9SGG3, ALA5_ARATH;  
Q9SLK6, ALA6_ARATH;  Q9LVK9, ALA7_ARATH;  Q9LK90, ALA8_ARATH;  
Q9SX33, ALA9_ARATH;  O60312, AT10A_HUMAN;  O54827, AT10A_MOUSE;  
O94823, AT10B_HUMAN;  B1AWN4, AT10B_MOUSE;  Q9P241, AT10D_HUMAN;  
Q9GKS6, AT10D_MACFA;  Q8K2X1, AT10D_MOUSE;  P98196, AT11A_HUMAN;  
P98197, AT11A_MOUSE;  Q9Y2G3, AT11B_HUMAN;  Q6DFW5, AT11B_MOUSE;  
Q9N0Z4, AT11B_RABIT;  Q8NB49, AT11C_HUMAN;  Q9QZW0, AT11C_MOUSE;  
Q29449, AT8A1_BOVIN;  Q9Y2Q0, AT8A1_HUMAN;  P70704, AT8A1_MOUSE;  
C7EXK4, AT8A2_BOVIN;  Q9NTI2, AT8A2_HUMAN;  P98200, AT8A2_MOUSE;  
O43520, AT8B1_HUMAN;  Q148W0, AT8B1_MOUSE;  D4AA47, AT8B1_RAT;  
Q5BL50, AT8B1_XENTR;  P98198, AT8B2_HUMAN;  P98199, AT8B2_MOUSE;  
O60423, AT8B3_HUMAN;  Q6UQ17, AT8B3_MOUSE;  Q8TF62, AT8B4_HUMAN;  
A3FIN4, AT8B5_MOUSE;  P39524, ATC3_YEAST;  Q12675, ATC4_YEAST;  
P32660, ATC5_YEAST;  P40527, ATC7_YEAST;  Q12674, ATC8_YEAST;  
Q09891, ATCX_SCHPO;  O36028, ATCZ_SCHPO;  O75110, ATP9A_HUMAN;  
O70228, ATP9A_MOUSE;  A1A4J6, ATP9B_BOVIN;  F1Q4S1, ATP9B_DANRE;  
O43861, ATP9B_HUMAN;  P98195, ATP9B_MOUSE;  D4ABB8, ATP9B_RAT;  
P21447, MDR1A_MOUSE;  P06795, MDR1B_MOUSE;  P21448, MDR1_CRIGR;  
P08183, MDR1_HUMAN;  P43245, MDR1_RAT;  P23174, MDR3_CRIGR;  
P21439, MDR3_HUMAN;  P21440, MDR3_MOUSE;  Q08201, MDR3_RAT;  
Q9U280, TAT1_CAEEL;  G5EBH1, TAT5_CAEEL;  Q10309, YD56_SCHPO;  
Q9UT43, YFRD_SCHPO;  O94296, YOOC_SCHPO;  

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