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ENZYME entry: EC 7.6.2.13

Accepted Name
ABC-type autoinducer-2 transporter.
Alternative Name(s)
Autoinducer-2 ABC transporter.
Autoinducer-2 transporting ATPase.
LsrACDB (gene names).
Reaction catalysed
ATP + H(2)O + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran-[AI-2-binding protein](Side 1) <=> ADP + phosphate + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran(Side 2) + [AI-2-binding protein](Side 1)
Comment(s)
  • ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of the signaling molecule (2R,4S)-2-methyl-2,3,3,4-tetrahydoxytetrahydrofuran (also known as autoinducer-2).
Cross-references
BRENDA7.6.2.13
EC2PDB7.6.2.13
ExplorEnz7.6.2.13
PRIAM enzyme-specific profiles7.6.2.13
KEGG Ligand Database for Enzyme Nomenclature7.6.2.13
IUBMB Enzyme Nomenclature7.6.2.13
IntEnz7.6.2.13
MEDLINEFind literature relating to 7.6.2.13
MetaCyc7.6.2.13
Rhea expert-curated reactions7.6.2.13
UniProtKB/Swiss-Prot
Q8XAY7, LSRA_ECO57;  B1XEA1, LSRA_ECODH;  A8A066, LSRA_ECOHS;  
B1IRU7, LSRA_ECOLC;  P77257, LSRA_ECOLI;  B1LFA2, LSRA_ECOSM;  
A4WER4, LSRA_ENT38;  A6TEB8, LSRA_KLEP7;  Q7N2D9, LSRA_PHOLL;  
Q2PBM0, LSRA_PHOLU;  Q2PBM3, LSRA_PHOTE;  P0C886, LSRA_SALCH;  
Q5PJE7, LSRA_SALPA;  A9MZG1, LSRA_SALPB;  Q8Z2X5, LSRA_SALTI;  
Q8ZKQ4, LSRA_SALTY;  Q0T4L9, LSRA_SHIF8;  Q83L12, LSRA_SHIFL;  
A1JJ55, LSRA_YERE8;  A7FMJ7, LSRA_YERP3;  Q1C138, LSRA_YERPA;  
B2K3G1, LSRA_YERPB;  Q0WJP9, LSRA_YERPE;  A9R074, LSRA_YERPG;  
Q1CN15, LSRA_YERPN;  A4TQL5, LSRA_YERPP;  Q66EY9, LSRA_YERPS;  
B1JLQ0, LSRA_YERPY;  

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