ID   7.6.2.2
DE   ABC-type xenobiotic transporter.
AN   ATP phosphohydrolase (steroid-exporting).
AN   MDR protein.
AN   multidrug-resistance protein.
AN   PDR protein.
AN   P-glycoprotein.
AN   pleiotropic-drug-resistance protein.
AN   steroid-transporting ATPase.
AN   xenobiotic-transporting ATPase.
CA   ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
CC   -!- An ATP-binding cassette (ABC) type transporter, characterized by the
CC       presence of two similar ATP-binding domains/proteins and two integral
CC       membrane domains/proteins.
CC   -!- Does not undergo phosphorylation during the transport process.
CC   -!- The enzymes from Gram-positive bacteria and eukaryotic cells export a
CC       number of drugs with unusual specificity, covering various groups of
CC       unrelated substances while ignoring some that are closely related
CC       structurally.
CC   -!- Several distinct enzymes may be present in a single eukaryotic cell.
CC   -!- Many of them also transport glutathione--drug conjugates (see
CC       EC 7.6.2.3) while others also show some 'flippase' activity (cf.
CC       EC 7.6.2.1).
CC   -!- Formerly EC 3.6.3.44.
DR   Q9LYS2, AB10C_ARATH;  Q9C8H1, AB11C_ARATH;  Q9C8H0, AB12C_ARATH;
DR   Q9SKX0, AB13C_ARATH;  Q9LZJ5, AB14C_ARATH;  Q7FB56, AB15C_ARATH;
DR   Q9C8G9, AB1C_ARATH ;  Q42093, AB2C_ARATH ;  Q9LK64, AB3C_ARATH ;
DR   Q7DM58, AB4C_ARATH ;  Q7GB25, AB5C_ARATH ;  Q8VZZ4, AB6C_ARATH ;
DR   Q9LK62, AB7C_ARATH ;  Q8LGU1, AB8C_ARATH ;  Q9M1C7, AB9C_ARATH ;
DR   Q9P7V2, ABC4_SCHPO ;  Q99758, ABCA3_HUMAN;  Q8R420, ABCA3_MOUSE;
DR   A0A0G2K1Q8, ABCA3_RAT  ;  Q2M3G0, ABCB5_HUMAN;  B5X0E4, ABCB5_MOUSE;
DR   Q4GZT4, ABCG2_BOVIN;  Q9UNQ0, ABCG2_HUMAN;  Q5MB13, ABCG2_MACMU;
DR   Q7TMS5, ABCG2_MOUSE;  Q8MIB3, ABCG2_PIG  ;  Q80W57, ABCG2_RAT  ;
DR   Q9CHL8, LMRA_LACLA ;  P97046, LMRA_LACLM ;  P57551, MDLA_BUCAI ;
DR   Q8K985, MDLA_BUCAP ;  Q89A97, MDLA_BUCBP ;  P77265, MDLA_ECOLI ;
DR   P57552, MDLB_BUCAI ;  Q8K984, MDLB_BUCAP ;  Q89A96, MDLB_BUCBP ;
DR   P0AAG7, MDLB_ECO57 ;  P0AAG6, MDLB_ECOL6 ;  P0AAG5, MDLB_ECOLI ;
DR   P21447, MDR1A_MOUSE;  P06795, MDR1B_MOUSE;  P21448, MDR1_CRIGR ;
DR   P16875, MDR1_ENTH1 ;  P08183, MDR1_HUMAN ;  Q06034, MDR1_LEIEN ;
DR   P43245, MDR1_RAT   ;  P21449, MDR2_CRIGR ;  P16876, MDR3_ENTH1 ;
DR   Q00449, MDR49_DROME;  P16877, MDR4_ENTH1 ;  Q00748, MDR65_DROME;
DR   P21441, MDR_LEITA  ;  P13568, MDR_PLAFF  ;  Q8HXQ5, MRP1_BOVIN ;
DR   Q6UR05, MRP1_CANLF ;  Q5F364, MRP1_CHICK ;  P33527, MRP1_HUMAN ;
DR   Q864R9, MRP1_MACFA ;  O35379, MRP1_MOUSE ;  Q8CG09, MRP1_RAT   ;
DR   Q92887, MRP2_HUMAN ;  Q8VI47, MRP2_MOUSE ;  Q28689, MRP2_RABIT ;
DR   Q63120, MRP2_RAT   ;  O15438, MRP3_HUMAN ;  B2RX12, MRP3_MOUSE ;
DR   O88563, MRP3_RAT   ;  O15439, MRP4_HUMAN ;  E9Q236, MRP4_MOUSE ;
DR   F1M3J4, MRP4_RAT   ;  O15440, MRP5_HUMAN ;  Q9R1X5, MRP5_MOUSE ;
DR   Q9QYM0, MRP5_RAT   ;  Q5T3U5, MRP7_HUMAN ;  Q8R4P9, MRP7_MOUSE ;
DR   Q96J66, MRP8_HUMAN ;  P34712, PGP1_CAEEL ;  P34713, PGP3_CAEEL ;
DR   Q9PT60, RBP1A_XENLA;  Q15311, RBP1_HUMAN ;  Q62172, RBP1_MOUSE ;
DR   Q62796, RBP1_RAT   ;  Q6Q876, SIRA_LEPMC ;
//