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ENZYME

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ENZYME entry: EC 7.6.2.3

Accepted Name
ABC-type glutathione-S-conjugate transporter
Alternative Name(s)
glutathione-S-conjugate-translocating ATPase
multidrug resistance-associated protein 1
YBT1 (gene name)
YCF1 (gene name)
Reaction catalysed
an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate
Comment(s)
  • A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates.
  • The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole.
  • Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
Cross-references
BRENDA7.6.2.3
EC2PDB7.6.2.3
ExplorEnz7.6.2.3
PRIAM enzyme-specific profiles7.6.2.3
KEGG Ligand Database for Enzyme Nomenclature7.6.2.3
IUBMB Enzyme Nomenclature7.6.2.3
IntEnz7.6.2.3
MEDLINEFind literature relating to 7.6.2.3
MetaCyc7.6.2.3
Rhea expert-curated reactions7.6.2.3
UniProtKB/Swiss-Prot
Q8HXQ5, MRP1_BOVINQ6UR05, MRP1_CANLFQ5F364, MRP1_CHICK
P33527, MRP1_HUMANQ864R9, MRP1_MACFAO35379, MRP1_MOUSE
Q8CG09, MRP1_RATQ92887, MRP2_HUMANQ8VI47, MRP2_MOUSE
Q28689, MRP2_RABITQ63120, MRP2_RATO15438, MRP3_HUMAN
B2RX12, MRP3_MOUSEO88563, MRP3_RATO15439, MRP4_HUMAN
E9Q236, MRP4_MOUSEF1M3J4, MRP4_RATO95255, MRP6_HUMAN
Q9R1S7, MRP6_MOUSEO88269, MRP6_RATQ5T3U5, MRP7_HUMAN
Q8R4P9, MRP7_MOUSEQ96J66, MRP8_HUMANQ9PT60, RBP1A_XENLA
Q15311, RBP1_HUMANQ62172, RBP1_MOUSEQ62796, RBP1_RAT
P39109, YCFI_YEASTP53049, YOR1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.-.-
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