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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.6.2.3

Accepted Name
ABC-type glutathione-S-conjugate transporter.
Alternative Name(s)
Glutathione-S-conjugate-translocating ATPase.
Multidrug resistance-associated protein 1.
YBT1 (gene name).
YCF1 (gene name).
Reaction catalysed
ATP + H(2)O + glutathione-S-conjugate(Side 1) <=> ADP + phosphate + glutathione-S-conjugate(Side 2)
Comment(s)
  • A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates.
  • The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole.
  • Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
Cross-references
BRENDA7.6.2.3
EC2PDB7.6.2.3
ExplorEnz7.6.2.3
PRIAM enzyme-specific profiles7.6.2.3
KEGG Ligand Database for Enzyme Nomenclature7.6.2.3
IUBMB Enzyme Nomenclature7.6.2.3
IntEnz7.6.2.3
MEDLINEFind literature relating to 7.6.2.3
MetaCyc7.6.2.3
UniProtKB/Swiss-Prot
P39109, YCFI_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-