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ENZYME entry: EC 7.6.2.8

Accepted Name
ABC-type vitamin B12 transporter.
Alternative Name(s)
Vitamin B12 ABC transporter.
Vitamin B12-transporting ATPase.
Reaction catalysed
ATP + H(2)O + vitamin B12-[cobalamin-binding protein](Side 1) <=> ADP + phosphate + vitamin B12(Side 2) + [cobalamin-binding protein](Side 1)
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • Does not undergo phosphorylation during the transport process.
  • A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives.
  • Formerly EC 3.6.3.33.
Cross-references
PROSITEPDOC00185
BRENDA7.6.2.8
EC2PDB7.6.2.8
ExplorEnz7.6.2.8
PRIAM enzyme-specific profiles7.6.2.8
KEGG Ligand Database for Enzyme Nomenclature7.6.2.8
IUBMB Enzyme Nomenclature7.6.2.8
IntEnz7.6.2.8
MEDLINEFind literature relating to 7.6.2.8
MetaCyc7.6.2.8
UniProtKB/Swiss-Prot
B0R5G4, BTUDA_HALS3;  Q9HQ18, BTUDA_HALSA;  A8AHA1, BTUD_CITK8;  
A7ZMH7, BTUD_ECO24;  B7US48, BTUD_ECO27;  B7MAS0, BTUD_ECO45;  
B7L6I2, BTUD_ECO55;  Q8X5W0, BTUD_ECO57;  B5YPZ7, BTUD_ECO5E;  
B7NTS2, BTUD_ECO7I;  B7MV91, BTUD_ECO81;  B7M1B8, BTUD_ECO8A;  
C4ZYH1, BTUD_ECOBW;  B1XG16, BTUD_ECODH;  A8A0Q1, BTUD_ECOHS;  
A1ABP5, BTUD_ECOK1;  Q0THB9, BTUD_ECOL5;  Q8FH28, BTUD_ECOL6;  
B1IPL8, BTUD_ECOLC;  P06611, BTUD_ECOLI;  B7N547, BTUD_ECOLU;  
B6I8R4, BTUD_ECOSE;  B1LE21, BTUD_ECOSM;  Q1RB86, BTUD_ECOUT;  
Q6D654, BTUD_PECAS;  Q7N3Q4, BTUD_PHOLL;  Q6LQ77, BTUD_PHOPR;  
Q57PU4, BTUD_SALCH;  B5FJ99, BTUD_SALDC;  B5QVV9, BTUD_SALEP;  
B4TGI0, BTUD_SALHS;  Q5PH81, BTUD_SALPA;  B5BA33, BTUD_SALPK;  
P63352, BTUD_SALTI;  P63351, BTUD_SALTY;  B2U358, BTUD_SHIB3;  
Q321G6, BTUD_SHIBS;  Q32FJ0, BTUD_SHIDS;  Q0T4R9, BTUD_SHIF8;  
Q7C1M3, BTUD_SHIFL;  Q3Z257, BTUD_SHISS;  A5F1V0, BTUD_VIBC3;  
A7MVV6, BTUD_VIBCB;  Q9KSL1, BTUD_VIBCH;  C3LLU1, BTUD_VIBCM;  
Q87Q38, BTUD_VIBPA;  B7VPD0, BTUD_VIBTL;  Q8D928, BTUD_VIBVU;  
Q7MLE6, BTUD_VIBVY;  A1JPQ1, BTUD_YERE8;  Q8ZDX6, BTUD_YERPE;  
Q66A01, BTUD_YERPS;  

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