ENZYME entry: EC 1.1.1.159

Accepted Name
7-alpha-hydroxysteroid dehydrogenase.
Reaction catalysed
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) <=> 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH
Comment(s)
  • Catalyzes the oxidation of the 7-alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms.
  • The Bacteroides fragilis and Clostridium enzymes can also utilize NADP(+).
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.159
EC2PDB1.1.1.159
ExplorEnz1.1.1.159
PRIAM enzyme-specific profiles1.1.1.159
KEGG Ligand Database for Enzyme Nomenclature1.1.1.159
IUBMB Enzyme Nomenclature1.1.1.159
IntEnz1.1.1.159
MEDLINEFind literature relating to 1.1.1.159
MetaCyc1.1.1.159
UniProtKB/Swiss-Prot
P0AET9, HDHA_ECO57;  P0AET8, HDHA_ECOLI;  

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