ENZYME entry: EC 1.1.1.159
| Accepted Name |
|---|
| 7-alpha-hydroxysteroid dehydrogenase.
|
| Reaction catalysed |
|---|
| 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) <=> 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH |
| Comment(s) |
|---|
- Catalyzes the oxidation of the 7-alpha-hydroxy group of bile acids
and alcohols both in their free and conjugated forms.
- The Bacteroides fragilis and Clostridium enzymes can also utilize
NADP(+).
|
| Cross-references |
|---|
| PROSITE | PDOC00060 |
| BRENDA | 1.1.1.159 |
| EC2PDB | 1.1.1.159 |
| ExplorEnz | 1.1.1.159 |
| PRIAM enzyme-specific profiles | 1.1.1.159 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.159 |
| IUBMB Enzyme Nomenclature | 1.1.1.159 |
| IntEnz | 1.1.1.159 |
| MEDLINE | Find literature relating to 1.1.1.159 |
| MetaCyc | 1.1.1.159 |
| UniProtKB/Swiss-Prot |
|
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