ENZYME entry: EC 1.1.1.176

Accepted Name
12-alpha-hydroxysteroid dehydrogenase.
Reaction catalysed
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NADP(+) <=> 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + NADPH
Comment(s)
  • Catalyzes the oxidation of the 12-alpha-hydroxy group of bile acids, both in their free and conjugated form.
  • Also acts on bile alcohols.
Cross-references
BRENDA1.1.1.176
EC2PDB1.1.1.176
ExplorEnz1.1.1.176
PRIAM enzyme-specific profiles1.1.1.176
KEGG Ligand Database for Enzyme Nomenclature1.1.1.176
IUBMB Enzyme Nomenclature1.1.1.176
IntEnz1.1.1.176
MEDLINEFind literature relating to 1.1.1.176
MetaCyc1.1.1.176
UniProtKB/Swiss-Prot
P21215, 12AH_CLOS4

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