ENZYME entry: EC 1.1.1.188

Accepted Name
Prostaglandin-F synthase.
Alternative Name(s)
PGD(2) 11-ketoreductase.
PGF synthetase.
Prostaglandin 11-ketoreductase.
Prostaglandin-D(2) 11-ketoreductase.
Prostaglandin-D(2) 11-reductase.
Prostaglandin-D(2) ketoreductase.
Prostaglandin-F synthetase.
Reaction catalysed
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) <=> (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
Comment(s)
  • Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).
  • Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
Cross-references
PROSITEPDOC00061
BRENDA1.1.1.188
EC2PDB1.1.1.188
ExplorEnz1.1.1.188
PRIAM enzyme-specific profiles1.1.1.188
KEGG Ligand Database for Enzyme Nomenclature1.1.1.188
IUBMB Enzyme Nomenclature1.1.1.188
IntEnz1.1.1.188
MEDLINEFind literature relating to 1.1.1.188
MetaCyc1.1.1.188
UniProtKB/Swiss-Prot
P42330, AK1C3_HUMAN;  Q5R7C9, AK1C3_PONAB;  P05980, PGFS1_BOVIN;  
P52897, PGFS2_BOVIN;  P22045, PGFS_LEIMA;  Q9GV41, PGFS_TRYBB;  
Q4DJ07, PGFS_TRYCC;  

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