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ENZYME entry: EC 1.1.1.197

Accepted Name
15-hydroxyprostaglandin dehydrogenase (NADP(+)).
Reaction catalysed
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) <=> (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH
Comment(s)
  • Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196).
  • May be identical with EC 1.1.1.189.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.197
EC2PDB1.1.1.197
ExplorEnz1.1.1.197
PRIAM enzyme-specific profiles1.1.1.197
KEGG Ligand Database for Enzyme Nomenclature1.1.1.197
IUBMB Enzyme Nomenclature1.1.1.197
IntEnz1.1.1.197
MEDLINEFind literature relating to 1.1.1.197
MetaCyc1.1.1.197
UniProtKB/Swiss-Prot
Q3SZD7, CBR1_BOVIN;  P16152, CBR1_HUMAN;  Q8MI29, CBR1_MACFA;  
P48758, CBR1_MOUSE;  Q28960, CBR1_PIG;  Q5RCU5, CBR1_PONAB;  
P47844, CBR1_RABIT;  P47727, CBR1_RAT;  

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