ENZYME entry: EC 1.1.1.206
| Accepted Name |
|---|
| Tropinone reductase I.
|
| Alternative Name(s) |
|---|
| TR-I. |
| Tropine dehydrogenase. |
| Tropinone reductase. |
| Reaction catalysed |
|---|
| Tropine + NADP(+) <=> tropinone + NADPH |
| Comment(s) |
|---|
- Also oxidizes other tropan-3-alpha-ols, but not the corresponding
beta-derivatives.
- Represents, along with EC 1.1.1.236, a branch point in tropane
alkaloid metabolism.
- Tropine (the product of EC 1.1.1.206) is incorporated into
hyoscyamine and scopolamine whereas pseudotropine (the product of
EC 1.1.1.236) is the first specific metabolite on the pathway to the
calystegines.
- Both enzymes are always found together in any given tropane-alkaloid-
producing species, have a common substrate, tropinone, and are
strictly stereospecific.
|
| Cross-references |
|---|
| PROSITE | PDOC00060 |
| BRENDA | 1.1.1.206 |
| EC2PDB | 1.1.1.206 |
| ExplorEnz | 1.1.1.206 |
| PRIAM enzyme-specific profiles | 1.1.1.206 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.206 |
| IUBMB Enzyme Nomenclature | 1.1.1.206 |
| IntEnz | 1.1.1.206 |
| MEDLINE | Find literature relating to 1.1.1.206 |
| MetaCyc | 1.1.1.206 |
| UniProtKB/Swiss-Prot |
|
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