ENZYME entry: EC 1.1.1.270

Accepted Name
3-beta-hydroxysteroid 3-dehydrogenase.
Alternative Name(s)
3-keto-steroid reductase.
3-KSR.
Reaction catalysed
A 3-beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + NADPH
Comment(s)
  • The enzyme acts on multiple 3-beta-hydroxysteroids.
  • Participates in the biosynthesis of zemosterol and cholesterol, where it catalyzes the reaction in the opposite direction to that shown.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.62.
Cross-references
BRENDA1.1.1.270
EC2PDB1.1.1.270
ExplorEnz1.1.1.270
PRIAM enzyme-specific profiles1.1.1.270
KEGG Ligand Database for Enzyme Nomenclature1.1.1.270
IUBMB Enzyme Nomenclature1.1.1.270
IntEnz1.1.1.270
MEDLINEFind literature relating to 1.1.1.270
MetaCyc1.1.1.270
UniProtKB/Swiss-Prot
P56937, DHB7_HUMAN;  O88736, DHB7_MOUSE;  Q62904, DHB7_RAT;  
Q74ZZ0, ERG27_ASHGO;  Q874K0, ERG27_CANAX;  Q6FIV3, ERG27_CANGA;  
Q6BNP0, ERG27_DEBHA;  Q6CJC2, ERG27_KLULA;  O74732, ERG27_SCHPO;  
Q6CE88, ERG27_YARLI;  Q12452, ERG27_YEAST;  

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