ENZYME entry: EC 1.1.1.62

Accepted Name
17-beta-estradiol 17-dehydrogenase.
Alternative Name(s)
17-beta-estradiol dehydrogenase.
17-beta-HSD.
17-beta-hydroxysteroid dehydrogenase.
20-alpha-hydroxysteroid dehydrogenase.
Estrogen 17-oxidoreductase.
Reaction catalysed
17-beta-estradiol + NAD(P)(+) <=> estrone + NAD(P)H
Comment(s)
  • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is B-specific with respect to NAD(P)(+).
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.62
EC2PDB1.1.1.62
ExplorEnz1.1.1.62
PRIAM enzyme-specific profiles1.1.1.62
KEGG Ligand Database for Enzyme Nomenclature1.1.1.62
IUBMB Enzyme Nomenclature1.1.1.62
IntEnz1.1.1.62
MEDLINEFind literature relating to 1.1.1.62
MetaCyc1.1.1.62
UniProtKB/Swiss-Prot
Q6P3L6, DH12A_DANRE;  Q5XG41, DH12A_XENLA;  Q6QA33, DH12B_DANRE;  
Q8AVY8, DH12B_XENLA;  Q8NBQ5, DHB11_HUMAN;  Q4JK73, DHB11_MACFA;  
Q9EQ06, DHB11_MOUSE;  Q5NVG2, DHB11_PONAB;  O57314, DHB12_ANAPL;  
Q5E9H7, DHB12_BOVIN;  Q53GQ0, DHB12_HUMAN;  Q4R5G7, DHB12_MACFA;  
O70503, DHB12_MOUSE;  Q6P7R8, DHB12_RAT;  Q28IU1, DHB12_XENTR;  
P14061, DHB1_HUMAN;  P51656, DHB1_MOUSE;  Q1WNP0, DHB1_PANTR;  
P51657, DHB1_RAT;  P37059, DHB2_HUMAN;  P51658, DHB2_MOUSE;  
Q62730, DHB2_RAT;  P56937, DHB7_HUMAN;  O88736, DHB7_MOUSE;  
Q62904, DHB7_RAT;  Q9GME3, DHB8_CALJA;  Q5TJF5, DHB8_CANFA;  
Q92506, DHB8_HUMAN;  P50171, DHB8_MOUSE;  Q9XT00, DHB8_PIG;  
Q6MGB5, DHB8_RAT;  Q3T001, H17B6_BOVIN;  O14756, H17B6_HUMAN;  
Q9R092, H17B6_MOUSE;  O54753, H17B6_RAT;  

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