ENZYME entry: EC 1.1.1.274

Accepted Name
2,5-didehydrogluconate reductase.
Alternative Name(s)
2,5-diketo-D-gluconate reductase.
Reaction catalysed
2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + NADPH
Comment(s)
  • Key enzyme in the microbial production of ascorbate.
  • Can also reduce ethyl 2-methylacetoacetate stereoselectively to ethyl (2R)-methyl-(3S)-hydroxybutanoate and can also accept some other beta-keto esters.
  • The identification of a bacterial beta-keto ester reductase as a 2,5- didehydrogluconate reductase links two previously separate areas of biocatalysis, i.e., asymmetric carbonyl reduction and microbial vitamin C production.
Cross-references
PROSITEPDOC00061
BRENDA1.1.1.274
EC2PDB1.1.1.274
ExplorEnz1.1.1.274
PRIAM enzyme-specific profiles1.1.1.274
KEGG Ligand Database for Enzyme Nomenclature1.1.1.274
IUBMB Enzyme Nomenclature1.1.1.274
IntEnz1.1.1.274
MEDLINEFind literature relating to 1.1.1.274
MetaCyc1.1.1.274
UniProtKB/Swiss-Prot
P06632, DKGA_CORSC;  Q8XBT6, DKGA_ECO57;  Q46857, DKGA_ECOLI;  
P58744, DKGA_SALTI;  Q8ZM06, DKGA_SALTY;  Q8ZI40, DKGA_YERPE;  
P15339, DKGB_CORSS;  Q8X7Z7, DKGB_ECO57;  P30863, DKGB_ECOLI;  
Q8Z988, DKGB_SALTI;  Q8ZRM7, DKGB_SALTY;  Q8ZH36, DKGB_YERPE;  

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