ENZYME entry: EC 1.1.1.283

Accepted Name
Methylglyoxal reductase (NADPH).
Alternative Name(s)
Lactaldehyde dehydrogenase (NADP(+)).
Methylglyoxal reductase (NADPH-dependent).
Reaction catalysed
(S)-lactaldehyde + NADP(+) <=> 2-oxopropanal + NADPH
Comment(s)
  • The enzyme from the yeast Saccharomyces cerevisiae catalyzes the reduction of a keto group in a number of compounds, forming enantiopure products.
  • Among the substrates are methylglyoxal (which is reduced to (S)- lactaldehyde), 3-methylbutanal, hexane-2,5-dione and 3-chloro-1- phenylpropan-1-one.
  • The enzyme differs from EC 1.1.1.78 which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
Cross-references
BRENDA1.1.1.283
EC2PDB1.1.1.283
ExplorEnz1.1.1.283
PRIAM enzyme-specific profiles1.1.1.283
KEGG Ligand Database for Enzyme Nomenclature1.1.1.283
IUBMB Enzyme Nomenclature1.1.1.283
IntEnz1.1.1.283
MEDLINEFind literature relating to 1.1.1.283
MetaCyc1.1.1.283
UniProtKB/Swiss-Prot
Q12068, GRE2_YEAST;  P83775, GRP2_CANAL;  O32210, GR_BACSU;  

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