To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.1.1.286

Accepted Name
Isocitrate--homoisocitrate dehydrogenase.
Alternative Name(s)
Homoisocitrate--isocitrate dehydrogenase.
Reaction catalysed
  • Isocitrate + NAD(+) <=> 2-oxoglutarate + CO(2) + NADH
  • (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) <=> 2-oxoadipate + CO(2) + NADH
Cofactor(s)
Mn(2+); NH(4)(+) or K(+).
Comment(s)
  • Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrate.
  • May play a role in both the lysine and glutamate biosynthesis pathways.
Cross-references
PROSITEPDOC00389
BRENDA1.1.1.286
EC2PDB1.1.1.286
ExplorEnz1.1.1.286
PRIAM enzyme-specific profiles1.1.1.286
KEGG Ligand Database for Enzyme Nomenclature1.1.1.286
IUBMB Enzyme Nomenclature1.1.1.286
IntEnz1.1.1.286
MEDLINEFind literature relating to 1.1.1.286
MetaCyc1.1.1.286
UniProtKB/Swiss-Prot
O59394, HICD_PYRHO

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-