To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 1.1.1.41

Accepted Name
Isocitrate dehydrogenase (NAD(+)).
Alternative Name(s)
Beta-ketoglutaric-isocitric carboxylase.
IDH.
Isocitrate dehydrogenase (NAD).
Isocitric acid dehydrogenase.
Isocitric dehydrogenase.
NAD dependent isocitrate dehydrogenase.
NAD isocitrate dehydrogenase.
NAD isocitric dehydrogenase.
NAD-linked isocitrate dehydrogenase.
NAD-specific isocitrate dehydrogenase.
Nicotinamide adenine dinucleotide isocitrate dehydrogenase.
Reaction catalysed
Isocitrate + NAD(+) <=> 2-oxoglutarate + CO(2) + NADH
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NADP(+) but much more slowly.
Cross-references
PROSITEPDOC00389
BRENDA1.1.1.41
EC2PDB1.1.1.41
ExplorEnz1.1.1.41
PRIAM enzyme-specific profiles1.1.1.41
KEGG Ligand Database for Enzyme Nomenclature1.1.1.41
IUBMB Enzyme Nomenclature1.1.1.41
IntEnz1.1.1.41
MEDLINEFind literature relating to 1.1.1.41
MetaCyc1.1.1.41
UniProtKB/Swiss-Prot
O13302, IDH1_AJECA;  Q8LFC0, IDH1_ARATH;  O94229, IDH1_KLULA;  
O13696, IDH1_SCHPO;  P28834, IDH1_YEAST;  P93032, IDH2_ARATH;  
O94230, IDH2_KLULA;  Q9USP8, IDH2_SCHPO;  P28241, IDH2_YEAST;  
P41563, IDH3A_BOVIN;  Q93714, IDH3A_CAEEL;  P54836, IDH3A_CANLF;  
Q9VWH4, IDH3A_DROME;  P50213, IDH3A_HUMAN;  Q28480, IDH3A_MACFA;  
P86225, IDH3A_MESAU;  Q9D6R2, IDH3A_MOUSE;  P56471, IDH3A_PIG;  
Q5R678, IDH3A_PONAB;  Q99NA5, IDH3A_RAT;  Q93353, IDH3B_CAEEL;  
O81796, IDH3_ARATH;  Q945K7, IDH5_ARATH;  Q8LG77, IDH6_ARATH;  
Q55BI2, IDHA_DICDI;  Q54B68, IDHB_DICDI;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-