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ENZYME entry: EC 1.1.1.334

Accepted Name
Methylecgonone reductase.
Reaction catalysed
Ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + NADPH
Comment(s)
  • The enzyme from the plant Erythroxylum coca catalyzes the penultimate step in the biosynthesis of cocaine.
  • In vivo the reaction proceeds in the opposite direction.
  • With NADH instead of NADPH the reaction rate is reduced to 14%.
  • The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates.
Cross-references
BRENDA1.1.1.334
EC2PDB1.1.1.334
ExplorEnz1.1.1.334
PRIAM enzyme-specific profiles1.1.1.334
KEGG Ligand Database for Enzyme Nomenclature1.1.1.334
IUBMB Enzyme Nomenclature1.1.1.334
IntEnz1.1.1.334
MEDLINEFind literature relating to 1.1.1.334
MetaCyc1.1.1.334
UniProtKB/Swiss-Prot
E7C196, MER_ERYCB

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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