To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC

Accepted Name
Methylecgonone reductase.
Reaction catalysed
Ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + NADPH
  • The enzyme from the plant Erythroxylum coca catalyzes the penultimate step in the biosynthesis of cocaine.
  • In vivo the reaction proceeds in the opposite direction.
  • With NADH instead of NADPH the reaction rate is reduced to 14%.
  • The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates.
PRIAM enzyme-specific profiles1.1.1.334
KEGG Ligand Database for Enzyme Nomenclature1.1.1.334
IUBMB Enzyme Nomenclature1.1.1.334
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-