ENZYME entry: EC 1.1.1.42

Accepted Name
Isocitrate dehydrogenase (NADP(+)).
Alternative Name(s)
Dual-cofactor-specific isocitrate dehydrogenase.
IDH.
IDP.
Isocitrate (NADP) dehydrogenase.
Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase.
Isocitrate dehydrogenase (NADP).
Isocitrate dehydrogenase (NADP-dependent).
NADP isocitric dehydrogenase.
NADP(+)-ICDH.
NADP(+)-IDH.
NADP(+)-linked isocitrate dehydrogenase.
NADP-dependent isocitrate dehydrogenase.
NADP-dependent isocitric dehydrogenase.
NADP-linked isocitrate dehydrogenase.
NADP-specific isocitrate dehydrogenase.
Oxalosuccinate decarboxylase.
Oxalsuccinic decarboxylase.
Triphosphopyridine nucleotide-linked isocitrate dehydrogenase- oxalosuccinate carboxylase.
Reaction catalysed
Isocitrate + NADP(+) <=> 2-oxoglutarate + CO(2) + NADPH
Cofactor(s)
Manganese or magnesium.
Comment(s)
  • Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NAD(+) but much more slowly.
Cross-references
PROSITEPDOC00389
BRENDA1.1.1.42
EC2PDB1.1.1.42
ExplorEnz1.1.1.42
PRIAM enzyme-specific profiles1.1.1.42
KEGG Ligand Database for Enzyme Nomenclature1.1.1.42
IUBMB Enzyme Nomenclature1.1.1.42
IntEnz1.1.1.42
MEDLINEFind literature relating to 1.1.1.42
MetaCyc1.1.1.42
UniProtKB/Swiss-Prot
Q9SRZ6, ICDHC_ARATH;  Q8LPJ5, ICDHP_ARATH;  Q9SLK0, ICDHX_ARATH;  
O13285, IDH1_CANTR;  P41560, IDH1_COLMA;  O13294, IDH2_CANTR;  
P41561, IDH2_COLMA;  Q9XSG3, IDHC_BOVIN;  Q75JR3, IDHC_DICDI;  
O75874, IDHC_HUMAN;  Q9Z2K9, IDHC_MICME;  Q9Z2K8, IDHC_MICOH;  
O88844, IDHC_MOUSE;  P83726, IDHC_NAEFO;  P20304, IDHC_PIG;  
Q5R9C5, IDHC_PONAB;  P41562, IDHC_RAT;  Q6XUZ5, IDHC_SHEEP;  
P50217, IDHC_SOLTU;  Q06197, IDHC_SOYBN;  P50218, IDHC_TOBAC;  
P41939, IDHC_YEAST;  P53982, IDHH_YEAST;  P79089, IDHP_ASPNG;  
Q04467, IDHP_BOVIN;  Q75JR2, IDHP_DICDI;  P48735, IDHP_HUMAN;  
Q4R502, IDHP_MACFA;  Q40345, IDHP_MEDSA;  P54071, IDHP_MOUSE;  
P33198, IDHP_PIG;  P56574, IDHP_RAT;  O14254, IDHP_SCHPO;  
P21954, IDHP_YEAST;  O67480, IDH_AQUAE;  O29610, IDH_ARCFU;  
P16100, IDH_AZOVI;  P39126, IDH_BACSU;  P96318, IDH_CALNO;  
Q8RQL9, IDH_COREF;  P50216, IDH_CORGL;  Q9ZH99, IDH_COXBU;  
P08200, IDH_ECOLI;  Q9ZN36, IDH_HELPJ;  P56063, IDH_HELPY;  
P65098, IDH_MYCBO;  P9WKL0, IDH_MYCTO;  P9WKL1, IDH_MYCTU;  
P50214, IDH_NOSS1;  Q1RJU4, IDH_RICBR;  Q92IR7, IDH_RICCN;  
Q4UKR1, IDH_RICFE;  Q9ZDR0, IDH_RICPR;  Q68XA5, IDH_RICTY;  
P50215, IDH_SPHYA;  Q5HF79, IDH_STAAC;  P65099, IDH_STAAM;  
P99167, IDH_STAAN;  Q6GG12, IDH_STAAR;  Q6G8N2, IDH_STAAS;  
Q8NW61, IDH_STAAW;  Q5HNL1, IDH_STAEQ;  Q8CNX4, IDH_STAES;  
Q59940, IDH_STRMU;  Q59985, IDH_STRSL;  P80046, IDH_SYNY3;  
P33197, IDH_THET8;  

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