ENZYME entry: EC 1.1.4.1
| Accepted Name |
|---|
| Vitamin-K-epoxide reductase (warfarin-sensitive).
|
| Alternative Name(s) |
|---|
| Phylloquinone epoxide reductase. |
| Vitamin K1 epoxide reductase. |
| Reaction catalysed |
|---|
| 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol <=> 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol |
| Comment(s) |
|---|
- In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin
K and possibly to vitamin K hydroquinone by 1,4-dithioerythritol,
which is oxidized to a disulfide; some other dithiols and
4-butanethiol can also act.
- Inhibited strongly by warfarin (cf. EC 1.1.4.2).
|
| Cross-references |
|---|
| BRENDA | 1.1.4.1 |
| EC2PDB | 1.1.4.1 |
| ExplorEnz | 1.1.4.1 |
| PRIAM enzyme-specific profiles | 1.1.4.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.4.1 |
| IUBMB Enzyme Nomenclature | 1.1.4.1 |
| IntEnz | 1.1.4.1 |
| MEDLINE | Find literature relating to 1.1.4.1 |
| MetaCyc | 1.1.4.1 |
| UniProtKB/Swiss-Prot |
|
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