ENZYME entry: EC 1.17.4.4

Accepted Name
Vitamin-K-epoxide reductase (warfarin-sensitive).
Alternative Name(s)
Phylloquinone epoxide reductase.
Vitamin K1 epoxide reductase.
Reaction catalysed
Phylloquinone + oxidized dithiothreitol + H(2)O <=> 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol
Comment(s)
  • Vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol, which is oxidized to a disulfide; some other dithiols and 4-butanethiol can also act.
  • Inhibited strongly by warfarin (cf. EC 1.17.4.5).
  • Formerly EC 1.1.4.1.
Cross-references
BRENDA1.17.4.4
EC2PDB1.17.4.4
ExplorEnz1.17.4.4
PRIAM enzyme-specific profiles1.17.4.4
KEGG Ligand Database for Enzyme Nomenclature1.17.4.4
IUBMB Enzyme Nomenclature1.17.4.4
IntEnz1.17.4.4
MEDLINEFind literature relating to 1.17.4.4
MetaCyc1.17.4.4
UniProtKB/Swiss-Prot
Q6B4J2, VKOR1_BOVIN;  Q9BQB6, VKOR1_HUMAN;  Q9CRC0, VKOR1_MOUSE;  
Q6TEK4, VKOR1_RAT;  Q8N0U8, VKORL_HUMAN;  Q6TEK5, VKORL_MOUSE;  
Q6TEK3, VKORL_RAT;  

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