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ENZYME entry: EC 126.96.36.199
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|Vitamin-K-epoxide reductase (warfarin-sensitive).
|Phylloquinone epoxide reductase.|
|Vitamin K1 epoxide reductase.|
|Phylloquinone + oxidized dithiothreitol + H(2)O <=> 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol|
- Vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin
K hydroquinone by 1,4-dithiothreitol, which is oxidized to a
disulfide; some other dithiols and 4-butanethiol can also act.
- Inhibited strongly by warfarin (cf. EC 188.8.131.52).
- Formerly EC 184.108.40.206.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
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