ENZYME entry: EC 1.1.4.2

Accepted Name
Vitamin-K-epoxide reductase (warfarin-insensitive).
Alternative Name(s)
Vitamin K 2,3-epoxide reductase.
Reaction catalysed
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol <=> 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
Comment(s)
  • In the reverse reaction, vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithioerythritol, which is oxidized to a disulfide.
  • Not inhibited by warfarin (cf. EC 1.1.4.1).
Cross-references
BRENDA1.1.4.2
EC2PDB1.1.4.2
ExplorEnz1.1.4.2
PRIAM enzyme-specific profiles1.1.4.2
KEGG Ligand Database for Enzyme Nomenclature1.1.4.2
IUBMB Enzyme Nomenclature1.1.4.2
IntEnz1.1.4.2
MEDLINEFind literature relating to 1.1.4.2
MetaCyc1.1.4.2

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