ENZYME entry: EC 1.1.5.3

Accepted Name
Glycerol-3-phosphate dehydrogenase.
Alternative Name(s)
FAD-dependent glycerol-3-phosphate dehydrogenase.
Flavin-linked glycerol-3-phosphate dehydrogenase.
Glycerol-3-phosphate CoQ reductase.
Glycerophosphate dehydrogenase.
L-glycerophosphate dehydrogenase.
sn-glycerol-3-phosphate dehydrogenase.
Reaction catalysed
sn-glycerol 3-phosphate + a quinone <=> glycerone phosphate + a quinol
Cofactor(s)
Flavin.
Comment(s)
  • An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.
  • In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.
  • In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.
  • This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.
  • Insect flight muscle uses only CoQ(10) as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ(9).
  • The enzyme is activated by calcium.
  • Formerly EC 1.1.2.1 and EC 1.1.99.5.
Cross-references
PROSITEPDOC00753
BRENDA1.1.5.3
EC2PDB1.1.5.3
ExplorEnz1.1.5.3
PRIAM enzyme-specific profiles1.1.5.3
KEGG Ligand Database for Enzyme Nomenclature1.1.5.3
IUBMB Enzyme Nomenclature1.1.5.3
IntEnz1.1.5.3
MEDLINEFind literature relating to 1.1.5.3
MetaCyc1.1.5.3
UniProtKB/Swiss-Prot
P0A9C1, GLPA_ECO57;  P0A9C0, GLPA_ECOLI;  P43799, GLPA_HAEIN;  
P0A9C2, GLPA_SHIFL;  A3MZ98, GLPB_ACTP2;  B3H0P4, GLPB_ACTP7;  
B0BTN3, GLPB_ACTPJ;  A6VKT7, GLPB_ACTSZ;  A8ADX8, GLPB_CITK8;  
A7ZP63, GLPB_ECO24;  B7UFQ3, GLPB_ECO27;  B7MG07, GLPB_ECO45;  
B7LAR0, GLPB_ECO55;  Q8XE13, GLPB_ECO57;  B5YX30, GLPB_ECO5E;  
B7NN59, GLPB_ECO7I;  B7MXS2, GLPB_ECO81;  B7M5S7, GLPB_ECO8A;  
C4ZU83, GLPB_ECOBW;  B1X8D6, GLPB_ECODH;  A8A2A7, GLPB_ECOHS;  
A1AD94, GLPB_ECOK1;  Q0TFK1, GLPB_ECOL5;  Q8FFN4, GLPB_ECOL6;  
B1IXU6, GLPB_ECOLC;  P13033, GLPB_ECOLI;  B7N5K6, GLPB_ECOLU;  
B6I7H1, GLPB_ECOSE;  B1LLJ4, GLPB_ECOSM;  Q1R9H5, GLPB_ECOUT;  
A4WCP1, GLPB_ENT38;  B7LM86, GLPB_ESCF3;  Q7VM49, GLPB_HAEDU;  
Q4QMN2, GLPB_HAEI8;  A5UE48, GLPB_HAEIE;  A5UHH2, GLPB_HAEIG;  
P43800, GLPB_HAEIN;  B8F6F3, GLPB_HAEPS;  B0R6S4, GLPB_HALS3;  
Q9HNS3, GLPB_HALSA;  Q0I239, GLPB_HISS1;  B0UVX7, GLPB_HISS2;  
B5XNY5, GLPB_KLEP3;  A6TBU4, GLPB_KLEP7;  Q65R09, GLPB_MANSM;  
Q9CL07, GLPB_PASMU;  Q6CZI7, GLPB_PECAS;  C6DH98, GLPB_PECCP;  
Q6LSE4, GLPB_PHOPR;  B5EYX0, GLPB_SALA4;  A9MJD3, GLPB_SALAR;  
Q57M68, GLPB_SALCH;  B5FNS6, GLPB_SALDC;  B5R258, GLPB_SALEP;  
B5RCB0, GLPB_SALG2;  B4TBF2, GLPB_SALHS;  B4SYV7, GLPB_SALNS;  
Q5PI45, GLPB_SALPA;  A9N5C9, GLPB_SALPB;  B5BCR1, GLPB_SALPK;  
B4TPG8, GLPB_SALSV;  Q8Z553, GLPB_SALTI;  Q8ZNG4, GLPB_SALTY;  
B2TW33, GLPB_SHIB3;  Q31Z75, GLPB_SHIBS;  Q32DU5, GLPB_SHIDS;  
Q0T2N9, GLPB_SHIF8;  Q83ML0, GLPB_SHIFL;  Q3YZW4, GLPB_SHISS;  
A5EZR7, GLPB_VIBC3;  Q9KLJ6, GLPB_VIBCH;  C3LW14, GLPB_VIBCM;  
Q5E0X7, GLPB_VIBF1;  B5ET22, GLPB_VIBFM;  Q8D7Y4, GLPB_VIBVU;  
Q7MF00, GLPB_VIBVY;  A1JIB0, GLPB_YERE8;  Q1CBK6, GLPB_YERPA;  
Q8ZAH6, GLPB_YERPE;  Q1CNF8, GLPB_YERPN;  Q66FX5, GLPB_YERPS;  
P64183, GLPD1_MYCBO;  P9WN80, GLPD1_MYCTO;  P9WN81, GLPD1_MYCTU;  
P64185, GLPD2_MYCBO;  P9WN78, GLPD2_MYCTO;  P9WN79, GLPD2_MYCTU;  
P18158, GLPD_BACSU;  P13035, GLPD_ECOLI;  P53435, GLPD_MYCLE;  
P52111, GLPD_PSEAE;  O83004, GLPD_PSETO;  Q2FHD8, GLPD_STAA3;  
Q2FYZ4, GLPD_STAA8;  Q2YXR5, GLPD_STAAB;  Q5HGD1, GLPD_STAAC;  
Q99UH2, GLPD_STAAM;  Q7A5V7, GLPD_STAAN;  Q6GHD4, GLPD_STAAR;  
Q6G9R2, GLPD_STAAS;  Q7A105, GLPD_STAAW;  Q5HPP0, GLPD_STAEQ;  
Q8CPE6, GLPD_STAES;  Q4L608, GLPD_STAHJ;  Q49X94, GLPD_STAS1;  
P74257, GLPD_SYNY3;  Q8SR40, GPDH_ENCCU;  A6QLU1, GPDM_BOVIN;  
P90795, GPDM_CAEEL;  Q54QC1, GPDM_DICDI;  P43304, GPDM_HUMAN;  
Q4R755, GPDM_MACFA;  A7DZP8, GPDM_MESAU;  Q64521, GPDM_MOUSE;  
P35571, GPDM_RAT;  O14400, GPDM_SCHPO;  P32191, GPDM_YEAST;  
Q9SS48, SDP6_ARATH;  

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