ENZYME entry: EC 1.11.1.8

Accepted Name
Iodide peroxidase.
Alternative Name(s)
Iodinase.
Iodotyrosine deiodase.
Iodotyrosine deiodinase.
Thyroid peroxidase.
Thyroperoxidase.
TPO.
Reaction catalysed
  • 2 iodide + H(2)O(2) + 2 H(+) <=> diiodine + 2 H(2)O
  • [Thyroglobulin]-L-tyrosine + iodide + H(2)O(2) <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H(2)O
  • [Thyroglobulin]-3-iodo-L-tyrosine + iodide + H(2)O(2) <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H(2)O
  • 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H(2)O(2) <=> [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H(2)O
  • [Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H(2)O(2) <=> [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H(2)O
Cofactor(s)
Heme.
Comment(s)
  • Thyroid peroxidase catalyzes the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine.
  • It catalyzes both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
Cross-references
PROSITEPDOC00394
BRENDA1.11.1.8
EC2PDB1.11.1.8
ExplorEnz1.11.1.8
PRIAM enzyme-specific profiles1.11.1.8
KEGG Ligand Database for Enzyme Nomenclature1.11.1.8
IUBMB Enzyme Nomenclature1.11.1.8
IntEnz1.11.1.8
MEDLINEFind literature relating to 1.11.1.8
MetaCyc1.11.1.8
UniProtKB/Swiss-Prot
Q8HYB7, PERT_CANFA;  P07202, PERT_HUMAN;  P35419, PERT_MOUSE;  
P09933, PERT_PIG;  P14650, PERT_RAT;  

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