ENZYME entry: EC 1.13.11.52
| Accepted Name |
|---|
| Indoleamine 2,3-dioxygenase.
|
| Alternative Name(s) |
|---|
| IDO. |
| Tryptophan pyrrolase. |
| Reaction catalysed |
|---|
- D-tryptophan + O(2) <=> N-formyl-D-kynurenine
- L-tryptophan + O(2) <=> N-formyl-L-kynurenine
|
| Cofactor(s) |
|---|
| Heme.
|
| Comment(s) |
|---|
- Requires ascorbic acid and methylene blue for activity.
- Has broader substrate specificity than EC 1.13.11.11.
- Is induced in response to pathological conditions and host-defense
mechanisms.
- While the enzyme is more active with D-tryptophan than L-tryptophan,
its only known function to date is in the metabolism of L-tryptophan.
- Superoxide radicals can replace O(2) as oxygen donor.
|
| Cross-references |
|---|
| PROSITE | PDOC00684 |
| BRENDA | 1.13.11.52 |
| EC2PDB | 1.13.11.52 |
| ExplorEnz | 1.13.11.52 |
| PRIAM enzyme-specific profiles | 1.13.11.52 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.13.11.52 |
| IUBMB Enzyme Nomenclature | 1.13.11.52 |
| IntEnz | 1.13.11.52 |
| MEDLINE | Find literature relating to 1.13.11.52 |
| MetaCyc | 1.13.11.52 |
| UniProtKB/Swiss-Prot |
|
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