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ENZYME entry: EC

Accepted Name
Beta-carotene 15,15'-dioxygenase.
Alternative Name(s)
Beta-carotene 15,15'-monooxygenase.
Carotene 15,15'-dioxygenase.
Carotene dioxygenase.
Reaction catalysed
Beta-carotene + O(2) <=> 2 all-trans-retinal
Fe cation.
  • The enzyme cleaves beta-carotene symmetrically, producing two molecules of all-trans-retinal.
  • Both atoms of the oxygen molecule are incorporated into the products.
  • The enzyme can also process beta-cryptoxanthin, 8'-apo-beta- carotenal, 4'-apo-beta-carotenal, alpha-carotene and gamma-carotene in decreasing order.
  • The presence of at least one unsubstituted beta-ionone ring in a substrate greater than C(30) is mandatory.
  • A prokaryotic enzyme has been reported from the uncultured marine bacterium 66A03, where it is involved in the proteorhodopsin system, which uses retinal as its chromophore.
  • Formerly EC 1.13.11.n2.
PRIAM enzyme-specific profiles1.13.11.63
KEGG Ligand Database for Enzyme Nomenclature1.13.11.63
IUBMB Enzyme Nomenclature1.13.11.63
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.13.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-