ENZYME entry: EC 1.14.99.36

Accepted Name
Beta-carotene 15,15'-monooxygenase.
Alternative Name(s)
Beta-carotene 15,15'-dioxygenase.
Carotene 15,15'-dioxygenase.
Carotene dioxygenase.
Reaction catalysed
Beta-carotene + O(2) <=> 2 all-trans-retinal
Cofactor(s)
Fe(2+).
Comment(s)
  • The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed (cf. EC 1.14.15.6).
  • Thus only one atom of the dioxygen is incorporated into retinal.
  • Formerly EC 1.13.11.21 and EC 1.18.3.1.
Cross-references
BRENDA1.14.99.36
EC2PDB1.14.99.36
ExplorEnz1.14.99.36
PRIAM enzyme-specific profiles1.14.99.36
KEGG Ligand Database for Enzyme Nomenclature1.14.99.36
IUBMB Enzyme Nomenclature1.14.99.36
IntEnz1.14.99.36
MEDLINEFind literature relating to 1.14.99.36
MetaCyc1.14.99.36
UniProtKB/Swiss-Prot
Q9I993, BCDO1_CHICK;  Q9HAY6, BCDO1_HUMAN;  Q9JJS6, BCDO1_MOUSE;  
Q91XT5, BCDO1_RAT;  

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