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ENZYME entry: EC 1.13.11.65

Accepted Name
Carotenoid isomerooxygenase.
Reaction catalysed
Zeaxanthin + O(2) <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
Comment(s)
  • The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects.
  • The enzyme accepts different all-trans carotenoids, including beta- carotene, alpha-carotene and lutein, and catalyzes the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration.
  • When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.
  • Formerly EC 1.14.13.164.
Cross-references
BRENDA1.13.11.65
EC2PDB1.13.11.65
ExplorEnz1.13.11.65
PRIAM enzyme-specific profiles1.13.11.65
KEGG Ligand Database for Enzyme Nomenclature1.13.11.65
IUBMB Enzyme Nomenclature1.13.11.65
IntEnz1.13.11.65
MEDLINEFind literature relating to 1.13.11.65
MetaCyc1.13.11.65
UniProtKB/Swiss-Prot
Q9VFS2, NINAB_DROME;  A8Y9I2, NINAB_GALME;  

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