ENZYME entry: EC 1.13.12.5

Accepted Name
Renilla-luciferin 2-monooxygenase.
Alternative Name(s)
Aequorin.
Luciferase.
Renilla-type luciferase.
Reaction catalysed
Renilla luciferin + O(2) <=> oxidized Renilla luciferin + CO(2) + light
Comment(s)
  • From the soft coral coelenterate Renilla reniformis.
  • The luciferin is bound to a luciferin-binding protein (BP-LH2).
  • The bioluminescent reaction between the luciferin complex, luciferase and oxygen is triggered by calcium ions.
  • In vivo, the excited state luciferin--luciferase complex undergoes the process of nonradiative energy transfer to an accessory protein, Renilla green fluorescent protein, which results in green bioluminescence.
  • In vitro, Renilla luciferase emits blue light in the absence of any green fluorescent protein.
Cross-references
BRENDA1.13.12.5
EC2PDB1.13.12.5
ExplorEnz1.13.12.5
PRIAM enzyme-specific profiles1.13.12.5
KEGG Ligand Database for Enzyme Nomenclature1.13.12.5
IUBMB Enzyme Nomenclature1.13.12.5
IntEnz1.13.12.5
MEDLINEFind literature relating to 1.13.12.5
MetaCyc1.13.12.5
UniProtKB/Swiss-Prot
P27652, LUCI_RENRE

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