ENZYME entry: EC 1.14.11.27

Accepted Name
[Histone H3]-lysine-36 demethylase.
Alternative Name(s)
H3-K36-specific demethylase.
Histone demethylase.
Histone-lysine (H3-K36) demethylase.
JHDM1A.
JmjC domain-containing histone demethylase 1A.
Reaction catalysed
  • Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) <=> protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2)
  • Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) <=> protein L-lysine + succinate + formaldehyde + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36.
  • Lysine residues exist in three methylation states (mono-, di- and trimethylated).
  • The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36.
  • It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.
Cross-references
BRENDA1.14.11.27
EC2PDB1.14.11.27
ExplorEnz1.14.11.27
PRIAM enzyme-specific profiles1.14.11.27
KEGG Ligand Database for Enzyme Nomenclature1.14.11.27
IUBMB Enzyme Nomenclature1.14.11.27
IntEnz1.14.11.27
MEDLINEFind literature relating to 1.14.11.27
MetaCyc1.14.11.27
UniProtKB/Swiss-Prot
Q75AL5, JHD1_ASHGO;  Q4WHB7, JHD1_ASPFU;  Q60V67, JHD1_CAEBR;  
Q95Q98, JHD1_CAEEL;  Q5A847, JHD1_CANAL;  Q6FPL6, JHD1_CANGA;  
P0CO41, JHD1_CRYNB;  P0CO40, JHD1_CRYNJ;  Q6BXJ4, JHD1_DEBHA;  
Q9VHH9, JHD1_DROME;  Q5AW75, JHD1_EMENI;  Q6CIC9, JHD1_KLULA;  
O94603, JHD1_SCHPO;  Q4P5U1, JHD1_USTMA;  Q6C423, JHD1_YARLI;  
P40034, JHD1_YEAST;  Q9Y2K7, KDM2A_HUMAN;  P59997, KDM2A_MOUSE;  
Q5U263, KDM2A_XENTR;  Q8NHM5, KDM2B_HUMAN;  Q6P1G2, KDM2B_MOUSE;  
Q640I9, KDM2B_XENLA;  Q1JP61, KDM8_BOVIN;  A8E534, KDM8_DANRE;  
Q8N371, KDM8_HUMAN;  Q9CXT6, KDM8_MOUSE;  Q497B8, KDM8_RAT;  
B5XF11, KDM8_SALSA;  B2GUS6, KDM8_XENTR;  A5PK74, NO66_BOVIN;  
C3XRY1, NO66_BRAFL;  Q5ZMM1, NO66_CHICK;  A3KP59, NO66_DANRE;  
Q9H6W3, NO66_HUMAN;  Q9JJF3, NO66_MOUSE;  D3ZU57, NO66_RAT;  
Q9UPP1, PHF8_HUMAN;  Q80TJ7, PHF8_MOUSE;  

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