ENZYME entry: EC 1.14.11.28

Accepted Name
Proline 3-hydroxylase.
Alternative Name(s)
P-3-H.
Reaction catalysed
L-proline + 2-oxoglutarate + O(2) <=> cis-3-hydroxy-L-proline + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • Unlike the proline hydroxylases involved in collagen biosynthesis (EC 1.14.11.2 and EC 1.14.11.7), this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme.
  • The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L- proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates.
Cross-references
BRENDA1.14.11.28
EC2PDB1.14.11.28
ExplorEnz1.14.11.28
PRIAM enzyme-specific profiles1.14.11.28
KEGG Ligand Database for Enzyme Nomenclature1.14.11.28
IUBMB Enzyme Nomenclature1.14.11.28
IntEnz1.14.11.28
MEDLINEFind literature relating to 1.14.11.28
MetaCyc1.14.11.28
UniProtKB/Swiss-Prot
P96010, P3H1_STRSQ;  O09345, P3H2_STRSQ;  

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