ENZYME entry: EC 1.14.11.32

Accepted Name
Codeine 3-O-demethylase.
Alternative Name(s)
Codeine O-demethylase.
Reaction catalysed
Codeine + 2-oxoglutarate + O(2) <=> morphine + formaldehyde + succinate + CO(2)
Cofactor(s)
Fe(2+).
Comment(s)
  • Requires Fe(2+).
  • Catalyzes a step in morphine biosynthesis.
  • The enzyme also catalyzes the 3-O-demethylation of thebaine to oripavine, with lower efficiency.
Cross-references
BRENDA1.14.11.32
EC2PDB1.14.11.32
ExplorEnz1.14.11.32
PRIAM enzyme-specific profiles1.14.11.32
KEGG Ligand Database for Enzyme Nomenclature1.14.11.32
IUBMB Enzyme Nomenclature1.14.11.32
IntEnz1.14.11.32
MEDLINEFind literature relating to 1.14.11.32
MetaCyc1.14.11.32
UniProtKB/Swiss-Prot
D4N502, DIOX3_PAPSO

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