ENZYME entry: EC 1.14.12.22
| Accepted Name |
|---|
| Carbazole 1,9a-dioxygenase.
|
| Alternative Name(s) |
|---|
| CARDO. |
| Reaction catalysed |
|---|
| 9H-carbazole + NAD(P)H + O(2) <=> 2'-aminobiphenyl-2,3-diol + NAD(P)(+) |
| Cofactor(s) |
|---|
| Iron; Iron-sulfur.
|
| Comment(s) |
|---|
- This enzyme catalyzes the first reaction in the pathway of carbazole
degradation.
- The enzyme attacks at the 1 and 9a positions of carbazole, resulting
in the formation of a highly unstable hemiaminal intermediate that
undergoes a spontaneous cleavage and rearomatization, resulting in
2'-aminobiphenyl-2,3-diol.
- In most bacteria the enzyme is a complex composed of a terminal
oxygenase, a ferredoxin, and a ferredoxin reductase.
- The terminal oxygenase component contains a nonheme iron center and a
Rieske [2Fe-2S] iron-sulfur cluster.
|
| Cross-references |
|---|
| BRENDA | 1.14.12.22 |
| EC2PDB | 1.14.12.22 |
| ExplorEnz | 1.14.12.22 |
| PRIAM enzyme-specific profiles | 1.14.12.22 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.12.22 |
| IUBMB Enzyme Nomenclature | 1.14.12.22 |
| IntEnz | 1.14.12.22 |
| MEDLINE | Find literature relating to 1.14.12.22 |
| MetaCyc | 1.14.12.22 |
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UniProtKB/Swiss-Prot entries corresponding to 1.14.12.-
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