ENZYME entry: EC 1.14.12.22

Accepted Name
Carbazole 1,9a-dioxygenase.
Alternative Name(s)
CARDO.
Reaction catalysed
9H-carbazole + NAD(P)H + O(2) <=> 2'-aminobiphenyl-2,3-diol + NAD(P)(+)
Cofactor(s)
Fe cation; Iron-sulfur.
Comment(s)
  • This enzyme catalyzes the first reaction in the pathway of carbazole degradation.
  • The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2'-aminobiphenyl-2,3-diol.
  • In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase.
  • The terminal oxygenase component contains a nonheme iron center and a Rieske [2Fe-2S] iron-sulfur cluster.
Cross-references
BRENDA1.14.12.22
EC2PDB1.14.12.22
ExplorEnz1.14.12.22
PRIAM enzyme-specific profiles1.14.12.22
KEGG Ligand Database for Enzyme Nomenclature1.14.12.22
IUBMB Enzyme Nomenclature1.14.12.22
IntEnz1.14.12.22
MEDLINEFind literature relating to 1.14.12.22
MetaCyc1.14.12.22
UniProtKB/Swiss-Prot
Q8G8B6, CARAA_PSERE;  D5IGG0, CARAA_SPHSX;  

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