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ENZYME entry: EC

Accepted Name
Senecionine N-oxygenase.
Alternative Name(s)
Senecionine monooxygenase (N-oxide-forming).
Reaction catalysed
Senecionine + NADPH + O(2) <=> senecionine N-oxide + NADP(+) + H(2)O
  • NADH cannot replace NADPH.
  • While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro- alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates.
  • Senecionine N-oxide is used by insects as a chemical defense: it is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P450 oxidase when absorbed by insectivores.
PRIAM enzyme-specific profiles1.14.13.101
KEGG Ligand Database for Enzyme Nomenclature1.14.13.101
IUBMB Enzyme Nomenclature1.14.13.101
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