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ENZYME entry: EC 1.14.13.101

Accepted Name
Senecionine N-oxygenase.
Alternative Name(s)
Senecionine monooxygenase (N-oxide-forming).
Reaction catalysed
Senecionine + NADPH + O(2) <=> senecionine N-oxide + NADP(+) + H(2)O
Comment(s)
  • NADH cannot replace NADPH.
  • While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro- alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates.
  • Senecionine N-oxide is used by insects as a chemical defense: it is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P450 oxidase when absorbed by insectivores.
Cross-references
BRENDA1.14.13.101
EC2PDB1.14.13.101
ExplorEnz1.14.13.101
PRIAM enzyme-specific profiles1.14.13.101
KEGG Ligand Database for Enzyme Nomenclature1.14.13.101
IUBMB Enzyme Nomenclature1.14.13.101
IntEnz1.14.13.101
MEDLINEFind literature relating to 1.14.13.101
MetaCyc1.14.13.101
UniProtKB/Swiss-Prot
Q8MP06, SNO1_TYRJA

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