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ENZYME entry: EC 126.96.36.199
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|Senecionine monooxygenase (N-oxide-forming).|
|Senecionine + NADPH + O(2) <=> senecionine N-oxide + NADP(+) + H(2)O|
- NADH cannot replace NADPH.
- While pyrrolizidine alkaloids of the senecionine and monocrotaline
types are generally good substrates (e.g. senecionine, retrorsine and
monocrotaline), the enzyme does not use ester alkaloids lacking an
hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-
alkaloids (e.g. sarracine) or unesterified necine bases (e.g.
senkirkine) as substrates.
- Senecionine N-oxide is used by insects as a chemical defense: it is
non-toxic, but it is bioactivated to a toxic form by the action of
cytochrome P450 oxidase when absorbed by insectivores.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
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