ENZYME entry: EC 1.14.13.121

Accepted Name
Premnaspirodiene oxygenase.
Alternative Name(s)
HPO.
Hyoscymus muticus premnaspirodiene oxygenase.
Reaction catalysed
(-)-vetispiradiene + 2 NADPH + 2 O(2) <=> solavetivone + 2 NADP(+) + 3 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the alpha-hydroxy compound, nootkatol, and this is converted into nootkatone.
  • 5-epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2-beta-hydroxy derivative which is not further oxidized.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.121
EC2PDB1.14.13.121
ExplorEnz1.14.13.121
PRIAM enzyme-specific profiles1.14.13.121
KEGG Ligand Database for Enzyme Nomenclature1.14.13.121
IUBMB Enzyme Nomenclature1.14.13.121
IntEnz1.14.13.121
MEDLINEFind literature relating to 1.14.13.121
MetaCyc1.14.13.121
UniProtKB/Swiss-Prot
A6YIH8, C7D55_HYOMU

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