ENZYME entry: EC 1.14.13.154

Accepted Name
Erythromycin 12 hydroxylase.
Reaction catalysed
Erythromycin D + NADPH + O(2) <=> erythromycin C + NADP(+) + H(2)O
Comment(s)
  • The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis.
  • It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B.
Cross-references
BRENDA1.14.13.154
EC2PDB1.14.13.154
ExplorEnz1.14.13.154
PRIAM enzyme-specific profiles1.14.13.154
KEGG Ligand Database for Enzyme Nomenclature1.14.13.154
IUBMB Enzyme Nomenclature1.14.13.154
IntEnz1.14.13.154
MEDLINEFind literature relating to 1.14.13.154
MetaCyc1.14.13.154
UniProtKB/Swiss-Prot
P48635, ERYK_SACEN

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