ENZYME

ENZYME entry: EC 1.14.13.50

Accepted Name

Pentachlorophenol monooxygenase.

Alternative Name(s)

PCB 4-monooxygenase.

PCB4MO.

PCP hydroxylase.

Pentachlorophenol 4-monooxygenase.

Pentachlorophenol dechlorinase.

Pentachlorophenol dehalogenase.

Pentachlorophenol hydroxylase.

Reaction catalysed

Pentachlorophenol + 2 NADPH + O(2) <=> 2,3,5,6-tetrachlorohydroquinone + 2 NADP(+) + chloride + H(2)O
2,3,5,6-tetrachlorophenol + NADPH + O(2) <=> 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H(2)O

Cofactor(s)

FAD.

Comment(s)

The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position.
The enzyme converts many polyhalogenated phenols into hydroquinones, and requires that a halogen substituent be present at C-2.
If C-4 carries a halogen substituent, reaction 1 is catalyzed, e.g. 2,4,6-triiodophenol is oxidized to 2,6-diiodohydroquinone; if C-4 is unsubstituted, reaction 2 is catalyzed.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature