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ENZYME entry: EC 1.14.13.53

Accepted Name
4'-methoxyisoflavone 2'-hydroxylase.
Alternative Name(s)
Isoflavone 2'-hydroxylase.
Isoflavone 2'-monooxygenase.
Reaction catalysed
Formononetin + NADPH + O(2) <=> 2'-hydroxyformononetin + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A.
  • Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
  • EC 1.14.13.89 is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.53
EC2PDB1.14.13.53
ExplorEnz1.14.13.53
PRIAM enzyme-specific profiles1.14.13.53
KEGG Ligand Database for Enzyme Nomenclature1.14.13.53
IUBMB Enzyme Nomenclature1.14.13.53
IntEnz1.14.13.53
MEDLINEFind literature relating to 1.14.13.53
MetaCyc1.14.13.53
UniProtKB/Swiss-Prot
Q6WNR0, C81E7_MEDTR

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