ENZYME entry: EC 1.14.13.77

Accepted Name
Taxane 13-alpha-hydroxylase.
Reaction catalysed
Taxa-4(20),11-dien-5-alpha-ol + NADPH + O(2) <=> taxa-4(20),11-dien-5-alpha,13-alpha-diol + NADP(+) + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
Involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
Cross-references
PROSITEPDOC00081
BRENDA1.14.13.77
EC2PDB1.14.13.77
ExplorEnz1.14.13.77
PRIAM enzyme-specific profiles1.14.13.77
KEGG Ligand Database for Enzyme Nomenclature1.14.13.77
IUBMB Enzyme Nomenclature1.14.13.77
IntEnz1.14.13.77
MEDLINEFind literature relating to 1.14.13.77
MetaCyc1.14.13.77
UniProtKB/Swiss-Prot
Q8W4T9, T13H_TAXCU

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